Long non-coding RNA LINC00152 promotes cell growth and invasion of papillary thyroid carcinoma by regulating the miR-497/BDNF axis

Journal of Cellular Physiology
Zhihui SunGuang Chen

Abstract

Long intergenic non-coding RNA 152 (LINC00152) was reported to be tightly linked to tumorigenesis and progression in multiple cancers. However, its biological role and modulatory mechanism in papillary thyroid carcinoma (PTC) has not been elucidated. In this study, we determined the expression levels of LINC00152 in PTC tissues and cell lines by quantitative real time polymerase chain reaction (qRT-PCR). Cell proliferation, colony formation, migration, and invasion were measured by a Cell Counting Kit-8 assay, colony formation analysis, wound healing, and transwell invasion assay, respectively. A luciferase reporter assay and qRT-PCR were used to determine whether LINC00152 interacts with miR-497 directly. We established a xenograft mouse model to examine the underlying molecular mechanism and effect of LINC00152 on tumor growth in vivo. We found that LINC00152 expression was significantly increased in PTC tissues and derived cell lines. LINC00152 knockdown significantly inhibited proliferation, colony formation, migration, and invasion in vitro, and impaired tumor growth in vivo. We revealed that LINC00152 functioned as a competing endogenous RNA to the miR-497 sponge, downregulating its downstream target brain-derived neurotr...Continue Reading

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Citations

Mar 7, 2020·Journal of Zhejiang University. Science. B·Hong Yu, Shu-Bin Li
Sep 18, 2020·Biomarkers in Medicine·Cheng-Ze ChenJin-Miao Qu
Nov 8, 2020·Cancers·Hossein TabatabaeianYvonne Tay
Apr 1, 2021·Seminars in Cancer Biology·Rui-Xin LinHong Zhang
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Donglei LiuSong Zhao
Jan 12, 2022·Journal of Clinical Laboratory Analysis·Jiayi ChenYang Xi
Oct 20, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Xiuhe ZouHan Luo

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