Long non-coding RNA LINC00514 promotes the proliferation and invasion through the miR-708-5p/HOXB3 axis in cervical squamous cell carcinoma.

Environmental Toxicology
Xiaoying LiuJing Zhang

Abstract

Long non-coding RNA (lncRNA) LINC00514 is a cancer-related lncRNA that has been proven to be implicated in the progression of several cancers. However, the biological function of LINC00514 in cervical squamous cell carcinoma (CSCC) remains unclear. Thus, we aimed to identify the LINC00514 expression profile in CSCC and determine its exact mechanism. Our results showed that the expression of LINC00514 was up-regulated in human CSCC tissues and cell lines. Knockdown of LINC00514 significantly inhibited the proliferation and invasion of CSCC cells, as well as suppressed tumorigenesis of CSCC in vivo. In addition, LINC00514 was found to work as a miRNA sponge for miR-708-5p and suppressed the expression of miR-708-5p in CSCC cells. Homeobox B3 (HOXB3) was found to be a target gene of miR-708-5p. Rescue assays demonstrated that miR-708-5p inhibitor attenuated the effects of LINC00514 knockdown on cell proliferation and invasion in CSCC cells. In addition, overexpression of HOXB3 reversed the inhibitory effects of miR-708-5p mimics on cell proliferation and invasion. Taken together, our findings for the first time elucidated that lncRNA LINC00514 promotes the proliferation and invasion through the miR-708-5p/HOXB3 axis in CSCC. Thus,...Continue Reading

References

Jun 12, 2002·Current Treatment Options in Oncology·S K Gibbons, H M Keys
Mar 3, 2006·Genes & Development·Marco Antonio Valencia-SanchezRoy Parker
Sep 23, 2006·Nature Reviews. Cancer·Richard Roden, T-C Wu
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jun 19, 2012·Biochemical and Biophysical Research Communications·Qiaoyan LiPuxiang Chen
Dec 12, 2012·Cancer Letters·Jing ChenYuanjie Niu
Oct 5, 2013·Science China. Life Sciences·Juanjuan ZhuXiaofei Zheng
Jan 7, 2014·Nature·Akinyemi I OjesinaMatthew Meyerson
Feb 12, 2017·Oncology Reports·Zhijie XuZhicheng Gong
Aug 21, 2018·Frontiers in Endocrinology·Jacob O'BrienChun Peng
Sep 5, 2018·Biochemical and Biophysical Research Communications·Yongzhen LiNa Li
Sep 7, 2018·Journal of Cellular and Molecular Medicine·Ying Huang
Dec 17, 2018·Biochemical and Biophysical Research Communications·Xiangya LiHuixia Liu
Jan 18, 2019·Journal of Cellular Biochemistry·Mingfu CuiBin Song
Jan 27, 2019·Pathology, Research and Practice·Shanshan HuangJianping Xiong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.