Dec 13, 2017

Long non-coding RNA LINC00959 predicts colorectal cancer patient prognosis and inhibits tumor progression

Zhenqiang SunWeitang Yuan


Long non-coding RNAs (lncRNAs) are increasingly implicated in tumorigenesis and cancer progression. This study focused on the relationship between the lncRNA LINC00959 and colorectal cancer (CRC). We found that LINC00959 expression was lower in CRC tissues than normal colorectal mucosae. High LINC00959 expression was negatively associated with TNM stage, distant metastasis, and lymphatic metastasis, and correlated with a better prognosis in 87 CRC cases. In vitro, LINC00959 knockdown enhanced colon cancer cell proliferation, invasion, and migration; upregulated N-cadherin and vimentin; and downregulated E-cadherin and Caspase-3. LINC00959 overexpression produced the opposite effects. These data suggest that LINC00959 inhibits tumor cell invasion and migration by suppressing epithelial-mesenchymal transition and promotes apoptosis through Caspase-3. LINC00959 may be a tumor suppressor and useful prognostic biomarker in CRC.

  • References30
  • Citations1


  • References30
  • Citations1


Mentioned in this Paper

Biological Markers
Tumor Suppressor Genes
VIM gene
TNM Staging System
Gene Knockdown Techniques
RNA, Untranslated
Cancer Progression

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