Abstract
Accumulated evidences have demonstrated that long non-coding RNAs (lncRNAs) are dysregulated and correlate with the pathophysiological basis of malignant tumors. The objective of this research is to uncover the possible molecular mechanism of MACC1-AS1 regarding the regulation of pancreatic carcinoma (PC) metastasis. lncRNA microarray and qRT-PCR were applied to identify differentially expressed lncRNA profile in PC. The function and role of MACC1-AS1 in PC were assessed via in vitro as well as in vivo assays. Luciferase analyses, RNA immunoprecipitation, and RNA pull-down were performed to determined the underlying MACC1-AS1 mechanisms. Numbers of differentially expressed lncRNAs in PC were identified via lncRNA microarrays, among which MACC1-AS1 was revealed as the most abundant lncRNA. The upregulation of MACC1-AS1 in PC was further confirmed in two expanded PC cohorts, which showed that MACC1-AS1 expression was upregulated in those PC patients with poor survival. Functionally, knockdown of MACC1-AS1 inhibited the proliferation as well as metastasis of PC cells. Meanwhile, MACC1-AS1 upregulated the expression of PAX8 protein, which promoted aerobic glycolysis and activated NOTCH1 signaling. Additionally, PAX8 was upregulated...Continue Reading
References
Feb 21, 2016·Cancer Discovery·Kristen B LongGregory L Beatty
Jan 20, 2017·British Journal of Cancer·Siddhartha P KarKate Lawrenson
Apr 19, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Lu-Lu ZhaiTong-Fa Ju
May 20, 2017·Cancer Gene Therapy·Y MaoH Wang
Jun 29, 2017·Journal of Cellular Physiology·Liang ZhaoMengtao Zhou
Jul 29, 2017·Scientific Reports·Haixiu YangXia Li
Aug 5, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Reetesh K Pai, Rish K Pai
Sep 25, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth S SilagiMakarand V Risbud
Oct 7, 2017·Journal of Cellular and Molecular Medicine·Xiaohui ZhaoChen Rufu
Oct 24, 2017·BioMed Research International·Kalupahana Irushi Pamodya Liyanage, Gamage Upeksha Ganegoda
Oct 29, 2017·Radiología·I Montejo GañánL H Ros Mendoza
Nov 11, 2017·Molecular Cancer·Hongzhe LiBaiyong Shen
Dec 19, 2017·Trends in Genetics : TIG·Qinyu SunKannanganattu V Prasanth
Mar 8, 2018·Molecular Cancer·Yang ZhaoMin Shi
Jun 19, 2018·Cancer Letters·Xiuhui ShiRenyi Qin
Oct 28, 2018·Cancer Communications·Yifan LianHongzhi Xu
Jan 25, 2019·Cancer Cell International·Hui ZhangYong Hu
Feb 5, 2019·Journal of Cellular Physiology·Lei Yue, Jing Guo
Feb 12, 2019·Oncogene·Wanming HeMin Shi
Citations
Apr 28, 2020·The Journal of International Medical Research·Yuling GuoZhengyu Zhan
May 14, 2020·Environmental Toxicology·Xiaojun WangYuanhua Liu
Jan 10, 2020·Aging·Hui TongZhecheng Zhu
Aug 21, 2020·Cell Cycle·Dahai ZhengXiaobing Xu
May 1, 2020·World Journal of Gastroenterology : WJG·Tao XuBin Niu
Jul 2, 2020·OncoTargets and Therapy·Lin ZhaoChunna Liu
Jun 18, 2020·Frontiers in Oncology·Ziyi Li, Xueying Sun
Mar 11, 2020·Frontiers in Oncology·Maria Lina TorneselloFranco Maria Buonaguro
Apr 11, 2020·Journal of Experimental & Clinical Cancer Research : CR·Zhonghou RongWenmao Geng
Sep 26, 2020·Cancer Cell International·Yizhi WangGary Guishan Xiao
Apr 11, 2020·OncoTargets and Therapy·Lixia YanYongxia Li
Dec 20, 2020·Environmental Toxicology·Bolin WuYuqing Zhang
Jan 12, 2021·Frontiers in Cell and Developmental Biology·Jia WenLongqing Li
Feb 9, 2021·Molecular Therapy. Nucleic Acids·Wenhua XueJie Zhao
Nov 19, 2020·Journal of Bone Oncology·Lei Wang
Jun 29, 2021·Frontiers in Oncology·Ammad Ahmad FarooqiWilliam C Cho
Jul 6, 2021·Frontiers in Oncology·Ji LiQingfang Zhu
Jul 8, 2021·Aging·Jin XuQinyun Sun