Long Non-coding RNA MIR4435-2HG Promotes Colorectal Cancer Proliferation and Metastasis Through miR-206/YAP1 Axis

Frontiers in Oncology
Xinhua DongXinguang Qiu

Abstract

Objective: Long non-coding RNAs (lncRNAs) are critical to colorectal cancer (CRC) progression. In the current study, the objective was the exploration of the role played by lncRNA MIR4435-2HG in CRC proliferation and metastasis. Methods: lncRNA MIR4435-2HG expression and its association with CRC were analyzed using database and clinical specimens. The influences exerted by MIR4435-2HG on cell proliferating process, invading process, and migrating process of CRC were identified after MIR4435-2HG knockdown. The influences exerted by MIR4435-2HG on tumor growth and metastasis were assessed in vivo. The underlying mechanistic associations between MIR4435-2HG, microRNA miR-206, and the transcription factor Yes-associated protein 1 (YAP1) were assessed using bioinformatics and a luciferase reporter gene assay. Results: MIR4435-2HG was highly expressed in CRC tissue in contrast with that in regular tissues and displayed relations to poor prognosis. MIR4435-2HG knockdown could suppress CRC cell proliferation, invasion, and migration. Moreover, MIR4435-2HG knockdown inhibited CRC growth and liver metastasis in vitro. We found MIR4435-2HG knockdown reduced YAP1, CTGF, AREG, vimentin, Snail, Slug, and Twist expression but enhanced E-cadhe...Continue Reading

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Citations

Oct 20, 2020·Frontiers in Oncology·Tao FanJie He
Jan 16, 2021·The Journal of Gene Medicine·Wenxin DaiDongwon Lee
Feb 11, 2021·International Journal of Molecular Sciences·Andrea AngiusMaria Rosaria De Miglio
Mar 16, 2021·Frontiers in Oncology·Zhiming LiaoChunlin Ou
May 4, 2021·The Journal of Clinical Investigation·Ciputra Adijaya HartanaXu G Yu
Jul 26, 2021·European Journal of Pharmacology·Chunyuan TangLushan Yu

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Methods Mentioned

BETA
surgical resection
transfection
transfections
Assay
electrophoresis
xenografts
xenograft
PCR

Software Mentioned

GraphPad Prism
GEPIA
Gene Expression Profiling Interactive Analysis ( GEPIA
Gene Expression Profiling Interactive Analysis ( GEPIA )

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