Long non-coding RNA NRON is downregulated in HCC and suppresses tumour cell proliferation and metastasis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zhicheng YaoMeihai Deng

Abstract

Dysregulation of long non-coding RNAs is a newly identified mechanism for tumour progression. Previous studies have suggested that the nuclear factor of activated T cells (NFAT) gene plays a very important role in cancer growth and metastasis. However, lncNRON is a newly identified repressor of NFAT, and its function is largely unknown, especially in hepatocellular carcinoma (HCC). Therefore, the expression levels of lncNRON in 215 pairs of HCC tissue were evaluated by qRT-PCR, and its relationship to clinicopathological parameters, recurrence, and survival was analysed. Furthermore, stably overexpressing lncNRON cell lines were constructed and evaluated for cell phenotype. Finally, we detected epithelial-to-mesenchymal transition (EMT) proteins to determine the underlying mechanism involved in lncNRON function. We observed that lncNRON was downregulated in HCC tumour tissues; low lncNRON expression was associated with poor tumour differentiation and the presence of vascular tumour thrombus, which tended to result in poor clinical outcomes, as demonstrated by the recurrence rate and survival curves. Functional analysis showed that lncNRON overexpression impaired colony formation and cell viability and inhibited cell migration a...Continue Reading

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Citations

Mar 22, 2019·Molecular and Cellular Biochemistry·Yapeng WangZhixiang Guo
May 10, 2020·International Journal of Oral Science·Ruilin ZhangYao Sun
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
Jun 24, 2021·Journal of Dental Research·J LiY Sun
Dec 11, 2021·Briefings in Bioinformatics·Eun-Gyeong ParkJin-Wu Nam
Dec 3, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jeannine HoepfnerThomas Thum

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