PMID: 26770456Jan 16, 2016Paper

Long non-coding RNA PCAT-1 over-expression promotes proliferation and metastasis in non-small cell lung cancer cells

International Journal of Clinical and Experimental Medicine
Bing ZhaoHui Zhan

Abstract

Long non-coding RNAs (lncRNAs) have emerged as major players in governing fundamental biological processes, and play a functional role in tumorigenesis. Prostate cancer-associated transcript1 (PCAT-1) is a novel lncRNA that promotes cell proliferation in prostate cancer. However, the role of PCAT-1 on non-small cell lung cancer (NSCLC) remains unclear. In the present study, we firstly investigated PCAT-1 expression in NSCLC tissues and cell lines by using quantitative real-time PCR (QRT-PCR). Our results indicated that PCAT-1 was increased in NSCLC tissues and cell lines. PCAT-1 suppression using PCAT-1 small hairpin RNA (shRNA) with A549 cells inhibited cell proliferation, migration and invasion, while over-expression of PCAT-1 by synthetic plasmid vectors was shown to promote cell proliferation, migration and invasion. Our data suggested that PCAT-1 could play an oncogenic role in NSCLC progression. Silencing PCAT-1 is a potential novel therapeutic approach for lung cancer.

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.