Long non-coding RNA SNHG5 promotes human hepatocellular carcinoma progression by regulating miR-26a-5p/GSK3β signal pathway.

Cell Death & Disease
Yarui LiXinlan Lu

Abstract

Accumulating evidence have suggested that long non-coding RNAs (lncRNAs) had malfunctioning roles in the development of human cancers. The present study aimed to investigate the role of lncRNA small nucleolar RNA host gene 5 (SNHG5) in hepatocellular carcinoma (HCC) progression using human tissues and cell lines. The quantitative real-time PCR results showed that SNHG5 was up-regulated in both HCC tissues and hepatoma cell lines and was closely associated with tumor size, hepatitis B virus infection, histologic grade, TNM stage, and portal vein tumor thrombus (PVTT) in HCC patients. Knockdown of SNHG5 induced apoptosis and repressed cell cycle progression, cell growth, and metastasis in hepatoma cell lines, whereas overexpression of SNHG5 had the opposite effects. In vivo functional assay, xenograft tumors grown from SNHG5-knockdown cells had smaller mean volumes than the tumors grown from negative control cells. Further investigations showed that SNHG5 may act as a competing endogenous RNA by competitively binding miR-26a-5p and thereby modulating the derepression of downstream target GSK3β, which were further confirmed by luciferase reporter assay. Functionally, SNHG5 promotes tumor growth and metastasis by activating Wnt/β-c...Continue Reading

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Citations

May 8, 2019·Journal of Cellular Physiology·Zahra Taherian-EsfahaniSoudeh Ghafouri-Fard
Jul 12, 2019·Bioscience Reports·Xiaojian LiLiangsheng Luo
Sep 24, 2019·Journal of Cellular Biochemistry·Yiping ZhuXiaoping Qian
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Jun 23, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dan GuoYarui Li
Feb 16, 2019·Journal of Experimental & Clinical Cancer Research : CR·Boran PangShouping Xu
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Apr 17, 2020·Molecular Cancer·Zhao HuangCanhua Huang
Aug 6, 2020·OncoTargets and Therapy·Wei HanWei Guan
Nov 28, 2018·International Journal of Molecular Sciences·Yang-Hsiang LinKwang-Huei Lin
May 18, 2020·Cell Death & Disease·Xing DuQifa Li
Oct 29, 2019·Cancer Biotherapy & Radiopharmaceuticals·Lei ChenMengyi Huang
Dec 16, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhen-Jiang LiJi-Fu Zheng
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Nov 10, 2020·Life Sciences·Md Nazim Uddin, Xiaosheng Wang
Aug 6, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shu-Lin HuangPei-Zhi Fan

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Methods Mentioned

BETA
FACS
transfection
xenograft
xenografts
PCR
electrophoresis
Assay

Software Mentioned

SPSS
TargetScan Human
Image J
Graphpad Prism
DIANA LncBase

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