Long Non-Coding RNA SNHG6 as a Potential Biomarker for Hepatocellular Carcinoma

Pathology Oncology Research : POR
Maryam Tahmasebi BirganiBaharak Farhangi

Abstract

Long Non-coding RNAs (lncRNAs) refer to all non-protein coding transcripts longer than 200 nucleotides. Their critical roles in different biological pathways have been already well established. Altered expression of lncRNAs can be involved in the cancer initiation and/or progression. Since patients with hepatocellular carcinoma (HCC) are usually diagnosed in late stages, developing diagnostic methods seems to be essential. In this study, the expression levels of different lncRNAs were systematically analysed in different genomic and transcriptome datasets. The analyses showed that SNHG6 is among the lncRNAs with distinctive dysregulation of expression and copy number variation in HCC tumors compared with normal tissues. The results also suggest that the dysregulation of SNHG6 is highly cancer type specific. Through co-occurrence analyses, we found that SNHG6 and its related co-expressed genes on 8q are involved in the structural integrity of ribosome and translation. This comprehensive in silico analysis, provides a resource for investigating SNHG6 in hepatocellular carcinoma and lays the groundwork for design of next researches.

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Citations

Mar 3, 2018·International Journal of Molecular Sciences·Manuela LanzafameSalvatore Piscuoglio
Mar 6, 2019·Journal of Cellular Physiology·Mohammad SarfiEhsan Khalili
Sep 17, 2020·Cancer Biotherapy & Radiopharmaceuticals·Dandan MaoYao Lv
Jul 30, 2020·Cancers·Laura ImedioJesús García-Foncillas
Jun 28, 2018·Pathology Oncology Research : POR·Hossein AnsariJavad Mohammadi Asl
May 26, 2018·The International Journal of Biological Markers·Qiang MengYang Sun
Mar 16, 2019·Frontiers in Genetics·Mohammadreza Hajjari, Saghar Rahnama
Feb 13, 2018·World Journal of Gastroenterology : WJG·Aya El KhodiryHend M El Tayebi
Jun 27, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nan Gao, Baoguo Ye
Apr 4, 2021·Genes·Tingsen Benson LimChing Kit Chen

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Methods Mentioned

BETA
RNA-seq
RNA seq

Software Mentioned

Cancer Genome Browser Plus
R
IlluminaHiseq
cBioPortal
GSEA
cgdsr
UCSC Cancer Genome Browser
Cancer Genome Browser
SPSS

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