Long non-coding RNA SPRY4-IT1 promotes the proliferation and invasion of U251 cells through upregulation of SKA2

Oncology Letters
Xiao-Jun HeBing Zhao

Abstract

The long non-coding RNA SPRY4-intronic transcript 1 (SPRY4-IT1) has been shown to promote the progression of cancer; however, the role of SPRY4-IT1 in glioma remains unclear. The present study demonstrated that SPRY4-IT1 expression was markedly increased in glioma tissues and cells compared with normal brain tissues, whereas knockdown of SPRY4-IT1 inhibited cell proliferation, migration, and invasion in U251 cells. Spindle and kinetochore associated complex subunit 2 (SKA2) was found to be a target of SPRY4-IT1 and was downregulated by SPRY4-IT1-knockdown. Additionally, SPRY4-IT1 expression was positively correlated with SKA2 in glioma tissues. To the best of our knowledge, the present study provides the first demonstration that SKA2 may have an oncogenic role in U251 cells. These results indicate that SPRY4-IT1 may serve a notable role in the molecular etiology of glioma and represents a potential target in glioma therapy.

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Sep 20, 2005·Lancet·M J van den BentUNKNOWN EORTC Radiotherapy and Brain Tumor Groups and the UK Medical Research Council
Nov 3, 2007·Genes & Development·Frank B FurnariWebster K Cavenee
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin S SmithMitchel S Berger
Jun 28, 2008·The Journal of Endocrinology·Lisa RiceDavid W Ray
Dec 17, 2008·Genomics·Rodrigo LouroSergio Verjovski-Almeida
Feb 26, 2009·Cell·Chris P PontingWolf Reik
May 18, 2010·Biochemical and Biophysical Research Communications·Guojun CaoNingsheng Shao
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Dec 3, 2010·The Journal of Pathology·Thalia A FaraziThomas Tuschl
Mar 12, 2011·Cancer Research·Wei ShiFei-Fei Liu
Apr 19, 2011·Cell·Takashi Nagano, Peter Fraser
May 10, 2011·Trends in Cell Biology·Orly Wapinski, Howard Y Chang
May 12, 2011·Cancer Research·Divya KhaitanRanjan J Perera
Jan 12, 2012·Journal of Cellular Biochemistry·Pengjun WangPiyun Sun
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip C De Witt HamerMitchel S Berger
Jul 3, 2013·The International Journal of Biochemistry & Cell Biology·Jie HeYu Li
Feb 11, 2014·Current Oncology Reports·Mohamed Ali Hamza, Mark Gilbert
May 9, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hai-Wei XieXiu-Feng Cao
Jun 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Phedias Diamandis, Kenneth D Aldape

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.