Long non-coding RNA TTN-AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR-153-3p/ZNRF2 axis

The Journal of Gene Medicine
Zhenghui CuiCaoxin Yan

Abstract

Long non-coding RNAs (lncRNAs) are crucial modulators in the tumorigenesis of numerous cancers, including papillary thyroid cancer (PTC). However, it is unclear whether lncRNA TTN antisense RNA 1 (TTN-AS1) can regulate PTC progression. The present study aimed to reveal the mechanism and function of TTN-AS1 in PTC. TTN-AS1 expression in 92 pairs PTC tissues and four PTC cells was measured via a quantitative reverse transcriptase-polymerase chain reaction assay. The relationship of TTN-AS1 expression and clinical pathological features of PTC patients was analyzed using a chi-squared test. The biofunction of TTN-AS1 in PTC was identified by loss or gain-of-function assays. Based on bioinformatics analysis and mechanism experiments, the molecular mechanism of TTN-AS1 was analyzed and identified. A high level of TTN-AS1 was observed in PTC tissues and cells. The expression level of TTN-AS1 is possibly associated with lymphatic metastasis, TNM stage and the overall survival of PTC patients. Functionally, TTN-AS1 knockdown inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition in PTC, whereas overexpression of TTN-AS1 led to the opposite results. Mechanistically, TTN-AS1 acted as a competing endogenous...Continue Reading

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Citations

Jan 22, 2020·Journal of Cellular Biochemistry·Linchi GuoXiaorong Zhan
Aug 28, 2020·Mediators of Inflammation·Liguo ZhuShenghong Zhang
May 21, 2020·Journal of Clinical Medicine·Weng-Tein GiBenjamin Meder
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Jun 7, 2021·World Journal of Surgical Oncology·Zhaoxia LinHan Gao
Jan 26, 2022·Environmental Science and Pollution Research International·Guanying Yang, Chunjie Zhang

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