Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2

Molecular Cancer
Ming-De HuangYong-Qian Shu

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC. Taurine Up-regulated Gene 1 (TUG1), a 7.1-kb lncRNA, recruiting and binding to polycomb repressive complex 2 (PRC2), is found to be disregulated in non-small cell lung carcinoma (NSCLC) and esophageal squamous cell carcinoma (ESCC). However, its clinical significance and potential role in HCC remain unclear. In this study, expression of TUG1 was analyzed in 77 HCC tissues and matched normal tissues by using quantitative polymerase chain reaction (qPCR). TUG1 expression was up-regulated in HCC tissues and the higher expression of TUG1 was significantly correlated with tumor size and Barcelona Clinic Liver Cancer (BCLC) stage. Moreover, silencing of TUG1 expression inhibited HCC cell proliferation, colony formation, tumorigenicity and induced apoptosis in HCC cell lines. We also found that TUG1 overexpression was induced by nuclear transcription factor SP1 and TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by b...Continue Reading

References

Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
Jul 25, 2006·Critical Reviews in Oncology/hematology·Alejandro FornerJordi Bruix
Aug 25, 2006·Nature Reviews. Cancer·Paraskevi A Farazi, Ronald A DePinho
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jan 5, 2011·Cancer Research·Miao-Chih TsaiHoward Y Chang
Apr 19, 2011·Cell·Takashi Nagano, Peter Fraser
Feb 23, 2012·Lancet·Alejandro FornerJordi Bruix
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Sep 11, 2012·Journal of Surgical Oncology·Yonghua HanZhiming Cai
Jan 2, 2013·Frontiers in Bioscience (Elite Edition)·Chun-Ming WongIrene Oi-Lin Ng
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Qiang ZhangJie Yao
Jul 6, 2013·Cell·Igor Ulitsky, David P Bartel
Feb 18, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Philipp G MaassSylvia Bähring
May 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rui-Min ChangLian-Yue Yang
Nov 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Youtao XuLin Xu
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal

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Citations

Nov 5, 2015·Journal of Cellular Biochemistry·Xiangbo Ruan
May 2, 2016·Genomics, Proteomics & Bioinformatics·Jacques J FrigaultPier Morin
Jun 25, 2016·Cell Proliferation·Zheng LiWilliam Ka Kei Wu
Sep 7, 2016·Trends in Genetics : TIG·Bethany SignalMarcel E Dinger
Oct 14, 2016·Journal of Experimental & Clinical Cancer Research : CR·Li-Min XuXiao-Dan Jiang
Dec 19, 2016·Wiley Interdisciplinary Reviews. RNA·Ritu Chaudhary, Ashish Lal
Feb 14, 2017·Drug Discoveries & Therapeutics·Hidenori Tani
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoxiong WangShiguang Zhao
Jun 10, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Zhi-Qiang LiWei-Jian Ai
Sep 6, 2017·International Journal of Molecular Sciences·Hsiang-Cheng ChiKwang-Huei Lin
Nov 18, 2017·Biomarkers in Cancer·Mrigaya Mehra, Ranjit Chauhan
Jul 27, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Heather H BurrisMichele R Hacker
Aug 14, 2018·Cancer Science·Yang LiWenbo Wang
Aug 13, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yang-Hsiang LinKwang-Huei Lin
Nov 24, 2018·Future Oncology·Nadiah AbuRahman Jamal
Oct 30, 2018·Nucleic Acids Research·Zhan TongYuan Zhou
Mar 27, 2019·Journal of Cellular Physiology·Soudeh Ghaforui-FardMohammad Taheri
Jan 11, 2018·Nature Reviews. Gastroenterology & Hepatology·Chun-Ming WongIrene Oi-Lin Ng
Jul 14, 2019·The Journal of Gene Medicine·Noha S RefaiIman Montasser
Oct 17, 2015·World Journal of Surgical Oncology·Yuan DangQiaojia Huang
Jan 1, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheng LiJianxiong Shen
Mar 30, 2019·Experimental Dermatology·Chuhan FuQinghai Zeng
Aug 5, 2017·Cancer Science·Yutaka KondoKeisuke Katsushima

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Methods Mentioned

BETA
transfection
RIP
ChIP
transfecting
flow cytometry
immunoprecipitation

Software Mentioned

CellQuest
JASPAR
SPSS
Quantity One

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