Long non-coding RNA XIST predicts worse prognosis in digestive system tumors: a systemic review and meta-analysis

Bioscience Reports
Xuefang LiuJiancheng Tu

Abstract

Increasing studies are indicating that long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is associated with the prognosis of cancer patients. However, the results have been disputed. Therefore, we aimed to further explore the prognostic value and clinical significance of XIST in various types of cancers. Then, we focussed our research on the comparison of the predictive value of XIST between digestive system tumors and non-digestive system tumors. We performed a systematic search by looking up PubMed, Embase, Cochrane Library, Web of Science, and Medline (up to 3 January 2018). Fifteen studies which matched our inclusion criteria with a total of 920 patients for overall survival and 867 patients for clinicopathological characteristics were included in this meta-analysis. Pooled hazard ratios (HR) and odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were calculated to summarize the effects. Our results suggested that high expression levels of XIST were associated with unfavorable overall survival in cancer patients (pooled HR = 1.81, 95% CI: 1.45-2.26). Additionally, we found that XIST was more valuable in digestive system tumors (pooled HR = 2.24, 95% CI: 1.73-2.92) than in non-dige...Continue Reading

References

Jun 21, 2011·The American Journal of Medicine·Minsig ChoiStephen A Geraci
Nov 24, 2011·Nature Reviews. Molecular Cell Biology·Jeannie T Lee
Jun 12, 2013·The International Journal of Biochemistry & Cell Biology·Chi Han Li, Yangchao Chen
May 13, 2014·Journal of Cancer Research and Clinical Oncology·Shuigen ZhouZhengyu Zhang
Dec 3, 2014·Current Opinion in Genetics & Development·Sharon F Briggs, Renee A Reijo Pera
Jan 20, 2015·Nature Genetics·Matthew K IyerArul M Chinnaiyan
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
May 20, 2015·Autoimmunity Reviews·Guo-Cui WuDong-Qing Ye
Jun 9, 2015·World Journal of Hepatology·Abhijeet WaghrayKv Narayanan Menon
Aug 19, 2015·Genome Biology·Andrea CerasePhilip Avner
Jan 29, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ruixue TangGang Chen
Aug 10, 2016·Biochemical and Biophysical Research Communications·Jing FangCheng Gong
Sep 14, 2016·Journal of Experimental & Clinical Cancer Research : CR·Dong-Liang ChenRui-Hua Xu
Oct 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Rong ZhengYawei Yuan
Nov 9, 2016·Circulation·Christian BärThomas Thum
Nov 30, 2016·Molecular Cytogenetics·Ilda Patrícia RibeiroIsabel Marques Carreira
Nov 30, 2016·International Journal of Clinical Oncology·Takahiro KojimaHiroyuki Nishiyama
Feb 25, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yichao MoQinshou Chen
Mar 16, 2017·Journal of Cellular Biochemistry·Wei WeiLing Tang
Mar 21, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xian ChenYunyuan Zhang
Sep 5, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yaoyao XiongLin Qi
Sep 28, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zhipeng LuHoward Y Chang
Oct 21, 2017·Current Opinion in Genetics & Development·Xiaowen HuLin Zhang
Nov 19, 2017·Nature Communications·Ramkrishna MitraChristine M Eischen
Dec 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tianyou LiuKeping He

❮ Previous
Next ❯

Software Mentioned

Stata SE12
Engauge Digitizer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
Chaojie LiangJiansheng Guo
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Cheng-Peng YuZheng-Ming Zhu
Clinica Chimica Acta; International Journal of Clinical Chemistry
Hua GeXianzhi Yang
© 2022 Meta ULC. All rights reserved