Long non-coding RNAs act as regulators of cell autophagy in diseases (Review)

Oncology Reports
Zhijie XuZhicheng Gong

Abstract

Identification of long non-coding RNAs (lncRNAs) has provided a substantial increase in our understanding of the non-coding transcriptome. Studies have revealed a crucial function of lncRNAs in the modulation of cell autophagy in vitro and in vivo, further contributing to the hallmarks of disease phenotypes. These findings have profoundly altered our understanding of disease pathobiology, and may lead to the emergence of new biological concepts underlying autophagy-associated diseases, such as the carcinomas. Studies on the molecular mechanism of the lncRNA-autophagy axis may offer additional avenues for therapeutic intervention and biomarker assessment. In this review, we discuss recent findings on the multiple molecular roles of regulatory lncRNAs in the signaling pathways of cell autophagy. The emerging knowledge in this rapidly advancing field will offer novel insights into human diseases, especially cancers.

References

Mar 26, 2008·Autophagy·Maria Høyer-Hansen, Marja Jäättelä
May 29, 2010·Genome Biology·Mohammad Ali FaghihiClaes Wahlestedt
Jun 8, 2012·Nature Reviews. Cancer·Nicola McCarthy
Jul 31, 2012·Molecular Cell·Je-Hyun YoonMyriam Gorospe
Sep 1, 2012·Nature Reviews. Drug Discovery·David C RubinszteinBeth Levine
Nov 13, 2012·Nature Cell Biology·Derrick GibbingsOlivier Voinnet
Feb 21, 2013·Autophagy·Derrick GibbingsOlivier Voinnet
May 28, 2013·Molecules and Cells·Stefan W RyterAugustine M K Choi
Aug 15, 2013·Pharmacological Reviews·Yan ChengJin-Ming Yang
Sep 21, 2013·Biochemical and Biophysical Research Communications·Jeffrey L FranklinRobert J Coffey
Dec 12, 2013·Nature Communications·Je-Hyun YoonMyriam Gorospe
Jun 14, 2014·PloS One·Shaoli DasJayprokas Chakrabarti
Jun 27, 2014·Seminars in Cell & Developmental Biology·Je-Hyun YoonMyriam Gorospe
Jul 2, 2014·Biochimica Et Biophysica Acta·Guanghong Jia, James R Sowers
Jul 22, 2014·Nature·Yuen-Yi TsengAnindya Bagchi
Aug 16, 2014·Autophagy·Yujie DengYing Yang
Sep 10, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jinsoo SongEun-Jung Jin
Oct 7, 2014·Biochimica Et Biophysica Acta·Cecilia EvangelistiAlberto M Martelli
Feb 11, 2015·Journal of Molecular and Cellular Cardiology·Maria-Teresa PiccoliThomas Thum
Apr 11, 2015·Nature Communications·Kun WangPei-Feng Li
Apr 16, 2015·BioMed Research International·Paola TiberioValentina Appierto
Sep 2, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Haitao ZhengJie Xu
Nov 19, 2015·Nucleic Acids Research·Anindya Bhattacharya, Yan Cui
Nov 22, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wen-Fang LiChang-An Liu
Nov 28, 2015·Nucleic Acids Research·Maria D ParaskevopoulouArtemis G Hatzigeorgiou
Dec 19, 2015·Nature Reviews. Cancer·Wynand P RoosBernd Kaina
Jan 14, 2016·Scientific Reports·Kamlesh PawarSoroush Sharbati
Jan 26, 2016·Molecular Aspects of Medicine·Hani ChoudhryAlan McIntyre

❮ Previous
Next ❯

Citations

Feb 23, 2018·International Journal of Molecular Sciences·Elżbieta PawłowskaJanusz Blasiak
Oct 9, 2019·Journal of Zhejiang University. Science. B·Gui-Zhen ZhengZhi-Yong Liu
Sep 14, 2018·Cell Communication and Signaling : CCS·Guo-Bin LiaoJian-Ying Bai
Apr 25, 2019·Journal of Experimental & Clinical Cancer Research : CR·Yuanliang YanZhijie Xu
Jan 30, 2019·Frontiers in Genetics·Md Zahirul Islam KhanHelen Ka Wai Law
Jul 8, 2020·Mechanisms of Ageing and Development·Shahrzad TalebianMohammad Reza Alivand
Feb 18, 2020·Biochemical and Biophysical Research Communications·Rong-Mao SunGuo-Qin Jiang
Mar 16, 2021·G3 : Genes - Genomes - Genetics·Mark J Bouska, Hua Bai
Apr 16, 2019·Oncology Research·Jie WeiZhijie Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

Chast

Related Concepts

Related Feeds

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Kenji TakahashiTushar Patel
International Journal of Molecular Sciences
Jin SunZongfang Li
© 2022 Meta ULC. All rights reserved