Long Non-Coding RNAs in Obesity-Induced Cancer

Non-coding RNA
Mabel Yin-Chun YauChi-Ming Wong

Abstract

Many mechanisms of obesity-induced cancers have been proposed. However, it remains unclear whether or not long non-coding RNAs (lncRNAs) play any role in obesity-induced cancers. In this article, we briefly discuss the generally accepted hypotheses explaining the mechanisms of obesity-induced cancers, summarize the latest evidence for the expression of a number of well-known cancer-associated lncRNAs in obese subjects, and propose the potential contribution of lncRNAs to obesity-induced cancers. We hope this review can serve as an inspiration to scientists to further explore the regulatory roles of lncRNAs in the development of obesity-induced cancers. Those findings will be fundamental in the development of effective therapeutics or interventions to combat this life-threatening adverse effect of obesity.

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Citations

May 2, 2019·Frontiers in Endocrinology·Andrea G Izquierdo, Ana B Crujeiras
Sep 2, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Andin Fosam, Rachel J Perry
Jan 15, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Federica ReyStephana Carelli
Dec 29, 2020·Medicinal Research Reviews·Qirong LuMaría-Aránzazu Martínez
Aug 16, 2021·Archives of Pharmacal Research·Aadrita HazraShakti P Pattanayak
Jun 10, 2021·Journal of Cellular Physiology·Krishan K ThakurAjaikumar B Kunnumakkara

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Methods Mentioned

BETA
histone acetylation

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