Long Non-Coding RNAs in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, and Therapy

Oncology Research and Treatment
Mohammad-Reza Mahmoudian-SaniGholam-Reza Mobini

Abstract

Thyroid cancer is a rare malignancy and accounts for less than 1% of malignant neoplasms in humans; however, it is the most common cancer of the endocrine system and responsible for most deaths from endocrine cancer. Long non-coding (Lnc)RNAs are defined as non-coding transcripts that are more than 200 nucleotides in length. Their expression deregulation plays an important role in the progress of cancer. These molecules are involved in physiologic cellular processes, genomic imprinting, inactivation of chromosome X, maintenance of pluripotency, and the formation of different organs via changes in chromatin, transcription, and translation. LncRNAs can act as a tumor suppressor genes or oncogenes. Several studies have shown that these molecules can interact with microRNAs and prevent their binding to messenger RNAs. Research has shown that these molecules play an important role in tumorigenicity, angiogenesis, proliferation, migration, apoptosis, and differentiation. In thyroid cancer, several lncRNAs (MALAT1, H19, BANCR, HOTAIR) have been identified as contributing factors to cancer development, and can be used as novel biomarkers for early diagnosis or even treatment. In this article, we study the newest lncRNAs and their role ...Continue Reading

References

Oct 21, 1993·Nature·Y HaoB Tycko
Sep 6, 2007·PloS One·Imad J MatoukEithan Galun
Jul 19, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Simona RossiGeorge A Calin
Nov 18, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lars Henning SchmidtCarsten Muller-Tidow
Feb 18, 2012·Nature·Blake WiedenheftJennifer A Doudna
Mar 7, 2013·Genetics·Johnny T Y KungJeannie T Lee
Apr 20, 2013·Experimental and Therapeutic Medicine·Min FanZhiming Wang
Jun 6, 2013·Journal of Cancer Epidemiology·Gabriella PellegritiRiccardo Vigneri
Jun 26, 2013·CA: a Cancer Journal for Clinicians·David F Schneider, Herbert Chen
Nov 28, 2013·Annual Review of Medicine·Tobias Carling, Robert Udelsman
Jun 19, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jun LvQian Wang
Jul 16, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mingzhao XingJustin Bishop
Aug 20, 2014·RNA Biology·Jinxiong HanWensheng Zhang
Nov 28, 2014·Oncotarget·Federico Di GesualdoMatteo Lulli
Feb 11, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenjun JiangDali Tian
May 9, 2015·Frontiers in Genetics·Aliaksandr A Yarmishyn, Igor V Kurochkin
Jun 11, 2015·Thyroid : Official Journal of the American Thyroid Association·Robert L FerrisUNKNOWN American Thyroid Association Surgical Affairs Committee
Aug 5, 2015·Molecular Medicine Reports·Xin Yu, Zheng Li
Dec 25, 2015·Genes & Development·Gayatri ArunDavid L Spector
Jan 30, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Bo XuWei Tang
Feb 22, 2016·Seminars in Nuclear Medicine·Ravinder K GrewalHeiko Schöder
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian-Kang HuangRui Zhou
Mar 30, 2017·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Hong-Mei LiJun-Qiang Chen
May 17, 2017·Experimental and Molecular Pathology·Ling-Ji GuoDong-Lin Luo

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Citations

Jul 2, 2020·Cancer Management and Research·Qiuli ShanNingning Chen
Jan 18, 2020·Cancers·Maria Chiara AnaniaAngela Greco
Jan 7, 2021·Molecular Genetics & Genomic Medicine·Wenya LiJing He
Mar 27, 2021·European Journal of Pharmacology·Nader Akbari DilmaghaniDavood Bashash
Apr 1, 2021·Seminars in Cancer Biology·Rui-Xin LinHong Zhang
May 28, 2021·Pathology, Research and Practice·Dan LvZaichun Deng
Jul 1, 2021·Cancer Management and Research·Shuping CaoLei Li
Sep 20, 2020·Cancer Letters·Jun CaoMeiyu Fang
Nov 2, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yanan ShanZhihua Yin

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