Long noncoding RNA ENST00000434223 suppressed tumor progression in non-small cell lung cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Xiaofei ChaiYongping Song

Abstract

In spite of the fact that the great progress has been made in the treatment of non-small cell lung cancer (NSCLC), the prognosis of NSCLC remains comparatively dismal. Therefore, it is of great value to identify novel effective diagnostic biomarkers and therapeutic targets of NSCLC. Emerging evidence has demonstrated the vital roles of long noncoding RNAs (lncRNAs) in cancer development. ENST00000434223 was recently identified as a lncRNA that is downregulated in early stage lung adenocarcinoma in a profiling study. However, little is known about its role in the development of NSCLC. In the present study, we found that ENST00000434223 was greatly downregulated in cancer tissues compared to adjacent normal tissues. ENST00000434223 overexpression suppressed the proliferation and migration in NSCLC cell lines in vitro. Moreover, ENST00000434223 overexpression reversed the epithelial-mesenchymal transition in NSCLC cell line. Our study suggests that ENST00000434223 may be a potential biomarker and a therapeutic target of NSCLC.

References

Sep 11, 1982·Nucleic Acids Research·J W Fickett
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Nov 29, 2013·Nucleic Acids Research·Chaoyong XieYi Zhao
Dec 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zhonghan LiTariq M Rana
Dec 20, 2014·Cancer Research·Maria V BogachekRonald J Weigel
Mar 12, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ping WangHongju Mao
Jun 24, 2015·Cancer Letters·Luis A AparicioAngélica Figueroa
Sep 12, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Namrata VijayvergiaCrystal S Denlinger
Sep 16, 2015·Cancers·Vishal BoolellVinod Ganju
Oct 21, 2015·Nature Genetics·Gina M DeNicolaLewis C Cantley
Oct 23, 2015·Journal of Experimental & Clinical Cancer Research : CR·Bojiang ChenWeimin Li

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