Long noncoding RNA GIHCG induces cancer progression and chemoresistance and indicates poor prognosis in colorectal cancer

OncoTargets and Therapy
Xiaohua JiangPing Zheng

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide, however, the mechanisms of CRC progression remain obscure. The present study investigated the clinical significance and functional role of long noncoding RNA (lncRNA) GIHCG in CRC. Expression of GIHCG was detected by quantitative real time polymerase chain reaction (qRT-PCR) in seven CRC cell lines and 110 CRC tissues. Comparison of clinicopathological characteristics in the high GIHCG expression group and the low GIHCG expression group was performed. The overall survival (OS) and progression-free survival (PFS) of the patients were depicted with Kaplan-Meier test and compared with Log-rank test. Univariate and multivariate analyses were carried out to detect the risk factors for poor OS and PFS. In addition, expression of GIHCG was silenced with siRNAs in LoVo cells and overexpressed with pcDNA3.1-GIHCG vector in SW480 cells, respectively. And the Transwell assay, Matrigel assay, colony formation assay and Cell Counting Kit-8 assay (CCK-8) were performed to investigate the role of GIHCG in the migration, invasion and proliferation of CRC cells. Besides, the role of GIHCG in chemoresistance was also detected. GIHCG was overexpressed in seven...Continue Reading

Citations

Oct 22, 2019·Frontiers in Oncology·Mercedes BermúdezRosalío Ramos-Payán
Sep 25, 2020·Asia-Pacific Journal of Clinical Oncology·Arash PoursheikhaniMohammad Amin Kerachian
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Dominik A BarthMartin Pichler
Jan 8, 2021·OncoTargets and Therapy·Weifeng ZhaoChaojie Wang
Mar 9, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Wenxiao JiangXueqiong Zhu
Mar 16, 2021·Frontiers in Oncology·Zhiming LiaoChunlin Ou

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