Long noncoding RNA H19 inhibits the proliferation of fetal liver cells and the Wnt signaling pathway

FEBS Letters
Shaobing WangFang Wang

Abstract

In this study, we found that H19 is the most strongly differentially expressed long noncoding RNA (lncRNA) during liver development. H19 may inhibit the proliferation of fetal liver cells by blocking the interaction between heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin, which results in gene transcriptional repression. Based on ChIP-seq analysis, we found that genes involved in the Wnt signaling pathway are enriched among hnRNP U-binding genes. Further investigation demonstrated that hnRNP U has opposing effects on cell proliferation and Wnt/β-catenin signaling pathway activity compared to H19 and that hnRNP U is very important in this process.

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Citations

Feb 24, 2017·International Journal of Molecular Sciences·Li ZhangKa Fai To
Sep 21, 2017·International Journal of Molecular Sciences·Peng ShenHui Ling
Jan 18, 2018·Chinese Medical Journal·Kang-Sheng LiuYa-Jun Chen
Nov 23, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Neha GoyalMalabika Datta
Apr 17, 2018·Non-coding RNA·Amanda Salviano-SilvaMaria Luiza Petzl-Erler
Aug 30, 2018·Non-coding RNA·Mabel Yin-Chun YauChi-Ming Wong
May 21, 2020·Cancers·Lysann Tietze, Sonja M Kessler
Aug 31, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jing XiongJiandie D Lin
Dec 16, 2018·Journal of Cellular Biochemistry·Min YangAiguo Tang

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