Long noncoding RNA LINC00261 regulates endometrial carcinoma progression by modulating miRNA/FOXO1 expression

Cell Biochemistry and Function
Qianjin FangShihua Du

Abstract

Long noncoding RNA LINC00261 was reported to be downregulated in multiple cancers. LINC00261 overexpression inhibits cancer cell proliferation, migration, and invasion. But the expression and function of LIN00261 in endometrial carcinoma are still elusive. We found that LINC00261 mRNA levels were downregulated in endometrial carcinoma, and LINC00261 overexpression inhibited endometrial carcinoma cell proliferation, migration, and invasion. miRNAs, including miR-182, miR-183, miR-153, miR-27a, and miR-96, were predicted to bind LINC00261 and FOXO1, and functioned to attenuate expression of LINC00261 and FOXO1. Overexpressed LINC00261 lowered these dissociative miRNAs, resulting in increase of FOXO1 protein levels. The knockdown of FOXO1 eliminated the suppression effect of overexpressed LINC00261 on endometrial carcinoma cell aggressiveness. LINC00261 promotes FOXO1 expression through reducing FOXO1-targeted miRNAs to suppress endometrial carcinoma cell proliferation, migration, and invasion. LINC00261 is downregulated in endometrial carcinoma and associated with metastasis of this cancer. LINC00261 elevates FOXO1 protein levels through reducing FOXO1-targeted miRNAs to suppress endometrial carcinoma cell proliferation, migratio...Continue Reading

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Citations

Nov 7, 2019·Journal of Cellular Biochemistry·Dongli ZhaoGuili Wang
Feb 27, 2020·The Journal of Pathology·Ioannis TsagakisJulie L Aspden
Aug 30, 2020·Journal of Cellular and Molecular Medicine·Feifei FanYi Zhang
Jun 19, 2019·Cancers·Romain DelangleGeoffroy Canlorbe
Jan 1, 2020·Basic and Clinical Andrology·Faruk HadziselimovicMichael B Stadler
Apr 4, 2021·International Journal of Molecular Sciences·Roberto PiergentiliFederica Perelli
Apr 4, 2021·Cancers·Amélia FavierGeoffroy Canlorbe
May 24, 2021·Cancer Cell International·Menggang ZhangWenzhi Guo
Aug 28, 2021·Healthcare·Anna Franca CavaliereFabrizio Signore
Feb 1, 2022·Nanoscale Research Letters·Yan ZhangShengchun Tong

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