Abstract
The dysregulation of long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) participates in the remodeling of electrophysiological/ion channel in cardiomyocytes during arrhythmia. The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is reported to be highly expressed in myocardial ischemia-reperfusion injury and offsets cardioprotective effects of fentanyl. However, the roles of MALAT1 and its related miRNAs during arrhythmia are poorly understood. In this study, the overexpression of MALAT1 was firstly indicated in cardiomyocytes from arrhythmic model rats. After downregulation of MALAT1 by RNA interference, transient outward potassium current (Ito), peak current density, and the levels of Kv4.2 and Kv4.3 channel proteins were increased in rat cardiomyocytes. Then, miR-200c was predicted and convinced to be a direct target of MALAT1, and high-mobility group box 1 (HMGB1) was verified to be a target of miR-200c during arrhythmia. HMGB1 expression reduced by the knockdown of MALAT1 was further decreased by miR-200c overexpression. In addition, cardiac Ito, peak current density, and the levels of Kv4.2 and Kv4.3 in arrhythmic model rats were detected to be negatively correlated with the expression of HMGB1, an...Continue Reading
References
Apr 1, 1989·The Journal of Physiology·D A EisnerM Valdeolmillos
Nov 6, 2008·Cardiovascular Research·Takashi KohnoSatoshi Ogawa
May 21, 2010·Journal of Molecular and Cellular Cardiology·Wenjuan LiuJie Liu
Dec 29, 2010·Journal of Cardiovascular Disease Research·Peng ZhouDayi Hu
Oct 1, 2013·BMC Genomics·Zuoming NieYaozhou Zhang
Jul 19, 2014·Circulation Research·Mélanie VausortYvan Devaux
Aug 8, 2014·Antioxidants & Redox Signaling·Simona Greco, Fabio Martelli
Feb 14, 2015·Circulation Research·Shizuka Uchida, Stefanie Dimmeler
Oct 18, 2015·International Journal of Cardiology·Mengyao ZhangXiang Zhou
Nov 11, 2015·Experimental Physiology·Ling ZhangBaopeng Tang
Dec 31, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anna BangertZiya Kaya
Jan 30, 2016·Diabetes·Huina ZhangYu Huang
Oct 30, 2016·Cancer Letters·Qiulian LiQingping Jiang
Oct 4, 2016·Molecular and Cellular Biochemistry·Gurinder Bir SinghMadhu Khullar
Nov 9, 2016·Circulation·Christian BärThomas Thum
Nov 20, 2016·Cell Biology International·Zhi-Hui ZhaoZhong-Yuan Xia
Jan 21, 2017·Circulation Research·Janika Viereck, Thomas Thum
Feb 25, 2017·Journal of Molecular and Cellular Cardiology·Monte S WillisScott J Bultman
Apr 5, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shutong ShenXinli Li
Apr 20, 2017·Stem Cell Research & Therapy·Zheng ZhangTaohong Hu
May 30, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi OgawaKaichiro Kamiya
Jul 21, 2017·PloS One·Po-Len LiuInn-Wen Chong
Aug 12, 2017·JACC. Basic to Translational Science·Lukas J MotlochFadi G Akar
Aug 18, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jinxia YuanYanfang Zhao
Aug 22, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Kouhei OhnoTetsuji Miura
Aug 26, 2017·Experimental Physiology·Vítor Scotta HentschkePedro Dal Lago
Citations
Nov 9, 2019·Epigenomics·Wei XiongJinqiao Qian
Apr 4, 2020·Journal of Biomedical Science·Chih-Fan YehKai-Chien Yang
Aug 6, 2020·International Journal of Molecular Sciences·Emre BektikDa-Zhi Wang
Dec 12, 2019·Cardiovascular Drugs and Therapy·Shuang WangZhihua Ruan
Jul 30, 2019·BioMed Research International·Huan ZhouJun-Ping Zhang
Dec 20, 2019·IUBMB Life·Youyou YanChunli Song
May 8, 2020·Molecular Therapy. Nucleic Acids·Rong TangZhan-Peng Huang
Jul 5, 2019·Pharmacology & Therapeutics·Yong ZhangBaofeng Yang
Apr 4, 2021·Non-coding RNA·Maryam Kay, Bahram M Soltani
Apr 17, 2021·Epigenomics·Xiang-Feng BaiLi-Zhong Sun
Jun 22, 2021·American Journal of Obstetrics and Gynecology·Emily C WillnerCarmen C Sucharov
Dec 2, 2021·Molecular Medicine Reports·Tao YaoXuetao Yan