Long noncoding RNA MORT overexpression inhibits cancer cell proliferation in oral squamous cell carcinoma by downregulating ROCK1

Journal of Cellular Biochemistry
Zhongzhi JinZhengjun Shang

Abstract

Long noncoding RNA (lncRNA) mortal obligate RNA transcript (MORT) was downregulated many types of cancer tissues, while its functionality in cancer biology is unclear. In the present study, we systemically investigated the involvement of lncRNA MORT in oral squamous cell carcinoma (OSCC). In the present study, we found that lncRNA MORT was downregulated, while rho-associated coiled-coil containing protein kinase 1 (ROCK1) messenger RNA was upregulated in cancer tissues than in adjacent healthy tissues of OSCC patients. In addition, expression levels of lncRNA MORT and ROCK1 were inversely correlated in both tumor tissues and healthy tissues. Follow-up study showed that low MORT level was significantly correlated with poor survival. Overexpression of lncRNA MORT inhibited the proliferation of OSCC cells and downregulated ROCK1. ROCK1 overexpression led to significantly promoted cell proliferation but showed no significant effect on MORT expression. In addition, ROCK1 overexpression attenuated the inhibitory effects of lncRNA MORT overexpression on the proliferation of OSCC cells. Therefore, lncRNA MORT overexpression may inhibit cancer cell proliferation in OSCC cells by downregulating ROCK1.

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Citations

Oct 1, 2020·Journal of Cellular and Molecular Medicine·Xin ChenYiqun Cao
Nov 23, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Anna Cecília Dias Maciel CarneiroVirgínia Oliveira Crema
Dec 10, 2019·Experimental and Molecular Pathology·Soudeh Ghafouri-FardMohammad Taheri
May 2, 2021·Scientific Reports·Shankargouda PatilAditi Chatterjee
Jun 3, 2021·International Journal of Molecular Sciences·Cing-Syuan LeiJing-Wen Shih
Jun 12, 2021·Pharmacogenomics and Personalized Medicine·Shuai PingJianghai Chen
Aug 8, 2021·International Journal of Molecular Sciences·Riccardo Di FioreJean Calleja-Agius
Jan 14, 2022·Genes & Genomics·Agnik Haldar, Ajay Kumar Singh

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