Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells.

Proceedings of the National Academy of Sciences of the United States of America
Abu Shufian Ishtiaq AhmedJiliang Zhou

Abstract

In response to vascular injury, vascular smooth muscle cells (VSMCs) may switch from a contractile to a proliferative phenotype thereby contributing to neointima formation. Previous studies showed that the long noncoding RNA (lncRNA) NEAT1 is critical for paraspeckle formation and tumorigenesis by promoting cell proliferation and migration. However, the role of NEAT1 in VSMC phenotypic modulation is unknown. Herein we showed that NEAT1 expression was induced in VSMCs during phenotypic switching in vivo and in vitro. Silencing NEAT1 in VSMCs resulted in enhanced expression of SM-specific genes while attenuating VSMC proliferation and migration. Conversely, overexpression of NEAT1 in VSMCs had opposite effects. These in vitro findings were further supported by in vivo studies in which NEAT1 knockout mice exhibited significantly decreased neointima formation following vascular injury, due to attenuated VSMC proliferation. Mechanistic studies demonstrated that NEAT1 sequesters the key chromatin modifier WDR5 (WD Repeat Domain 5) from SM-specific gene loci, thereby initiating an epigenetic "off" state, resulting in down-regulation of SM-specific gene expression. Taken together, we demonstrated an unexpected role of the lncRNA NEAT1 ...Continue Reading

References

Jan 15, 1999·Acta Physiologica Scandinavica·G K Owens
Jan 16, 2002·Current Biology : CB·Archa H FoxAngus I Lamond
May 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhigao WangEric N Olson
Jun 6, 2003·Journal of Molecular and Cellular Cardiology·Joseph M Miano
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Oct 22, 2005·Cell·Kannanganattu V PrasanthDavid L Spector
Sep 30, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jacob F BentzonErling Falk
Apr 4, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Jiliang ZhouB Paul Herring
Sep 2, 2009·The Journal of Cell Biology·Charles S Bond, Archa H Fox
Jun 26, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan-Marcus DanielDaniel G Sedding
Mar 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Raphael A NemenoffMary C M Weiser-Evans
Mar 30, 2011·The Journal of Cell Biology·Shinichi NakagawaTetsuro Hirose
Sep 8, 2012·Nature·Sarah DjebaliThomas R Gingeras
Jan 18, 2013·RNA Biology·Takao Naganuma, Tetsuro Hirose
Jul 6, 2013·Cell·Igor Ulitsky, David P Bartel
Nov 1, 2013·Molecular Biology of the Cell·Tetsuro HiroseGérard Pierron
Dec 4, 2013·Nature Reviews. Genetics·Alessandro Fatica, Irene Bozzoni
Mar 1, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert D BellJoseph M Miano
Mar 8, 2014·Circulation Research·Katharina M MichalikStefanie Dimmeler
Oct 16, 2014·RNA·Laura StandaertJean-Christophe Marine
Nov 22, 2014·Nature Communications·Dimple ChakravartyMark A Rubin
Mar 10, 2015·Journal of Biomedical Research·Joseph M Miano
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tetsuya KawaguchiTetsuro Hirose
Jan 23, 2016·Frontiers in Behavioral Neuroscience·Kristopher M BuntingAlmira Vazdarjanova
Jul 23, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Jinjing ZhaoXiaochun Long
Jan 21, 2017·Cell Proliferation·Xin YuWilliam Ka Kei Wu

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Citations

Jan 21, 2020·Clinical Genetics·Kevin D Mangum, Mark A Farber
May 6, 2020·The FEBS Journal·Eithne Margaret Maguire, Qingzhong Xiao
Mar 25, 2020·Current Opinion in Cardiology·Sadhan DasRama Natarajan
Feb 19, 2020·Current Opinion in Cardiology·Joseph B Moore, Shizuka Uchida
Jul 24, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Jacob B Pierce, Mark W Feinberg
Aug 25, 2020·Essays in Biochemistry·Yang Wang, Ling-Ling Chen
Nov 20, 2019·Heart Failure Reviews·Qi JinZhihong Liu
Mar 7, 2019·Frontiers in Cardiovascular Medicine·Adam W TurnerClint L Miller
Jun 28, 2019·Cell Death & Disease·Shanshan WangBo Zuo
Mar 29, 2020·Cellular and Molecular Life Sciences : CMLS·Ziqiang WangWeiren Huang
Aug 11, 2020·Current Atherosclerosis Reports·Tatjana Josefs, Reinier A Boon
May 1, 2020·European Heart Journal·Ulf LandmesserThomas F Lüscher
Jul 30, 2019·BioMed Research International·Huan ZhouJun-Ping Zhang
Dec 20, 2020·The FEBS Journal·Koh OnoTakeshi Kimura
Jan 28, 2021·Environmental Science and Pollution Research International·Quanlong HongYi Zhang
Nov 5, 2020·Non-coding RNA·Gabriel Pisani, Byron Baron
Nov 2, 2020·Journal of Translational Medicine·S GrecoF Martelli
Jan 9, 2021·BioMed Research International·Abulaihaiti MaitiseyitiXiaohu Ge
Nov 25, 2020·Molecular Therapy. Nucleic Acids·Yeong-Hwan LimYoung-Kook Kim
Mar 6, 2021·Molecular Therapy. Nucleic Acids·Xi YangYonghong Li
Mar 23, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Finn McCluggage, Archa H Fox
Apr 10, 2021·Atherosclerosis·Urna KansakarGaetano Santulli
May 1, 2021·Biomolecules·Diamantis I TsilimigrasFragiska Sigala
Jun 5, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Shinichi NakagawaTetsuro Hirose
Jun 6, 2021·BMC Genomics·Sébastien RiquierThérèse Commes
May 28, 2021·Frontiers in Cardiovascular Medicine·Jiawen LiYifei Li
Jul 25, 2021·Journal of Molecular and Cellular Cardiology·Nikolaos I VlachogiannisKonstantinos Stellos
Jul 21, 2021·Journal of Medicinal Chemistry·Xin ChenXiaoke Guo
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiongyu LiJun Peng
Feb 16, 2019·European Journal of Pharmacology·Xiaojiang QinQingshan Li

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