Long noncoding RNA NKILA enhances the anti-cancer effects of baicalein in hepatocellular carcinoma via the regulation of NF-κB signaling

Chemico-biological Interactions
Xiaolan YuJiyi Xia

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancer and leading cause of cancer-related death worldwide. Baicalein, a principle flavonoid, has shown attractive anti-cancer effects on HCC. However, the underlying molecular mechanisms and influencing factors contributing to the anti-cancer effects of baicalein on HCC are still largely unknown. Long noncoding RNAs (lncRNAs) have been revealed to be fascinating therapeutic targets for cancers. The roles of NF-κB Interacting LncRNA (NKILA) are recently explored in several cancers. However, the expressions, clinical significances, roles and action mechanisms of NKILA in the anti-cancer effects of baicalein on HCC are unknown. In this study, we found that NKILA is down-regulated in HCC and reduced expression of NKILA indicts poor survival of HCC patients. Functional assays showed that overexpression of NKILA enhances the roles of baicalein on HCC cell proliferation inhibition, apoptosis induction, and migration inhibition in vitro and tumor growth suppression in vivo. Conversely, knockdown of NKILA suppresses the effects of baicalein. Mechanistically, we found that NKILA inhibits IκBα phosphorylation, NF-κB nuclear translocation, and NF-κB activity. NKILA also enhances the...Continue Reading

Citations

Apr 7, 2020·Journal of Clinical Laboratory Analysis·Jinming Han, Xiaohan Shen
Mar 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Chongyang MaFafeng Cheng
May 2, 2020·Cancer Biotherapy & Radiopharmaceuticals·Neng WanJing Wang
Jul 16, 2020·Non-coding RNA·Marcin WysoczynskiShizuka Uchida
Oct 23, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Subash C GuptaKishore B Challagundla
Aug 27, 2018·Biochemical and Biophysical Research Communications·Qing ZhouZhi-Jun Chen
Apr 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bashdar Mahmud HussenSoudeh Ghafouri-Fard
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
Nov 17, 2021·Critical Reviews in Food Science and Nutrition·Mina HomayoonfalBahman Yousefi

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