Long noncoding RNA nuclear enriched abundant transcript 1/miRNA-124 axis correlates with increased disease risk, elevated inflammation, deteriorative disease condition, and predicts decreased survival of sepsis

Medicine
Fuyun HeQinghe Huang

Abstract

We aimed to investigate the correlation of long noncoding RNA nuclear enriched abundant transcript 1 (lnc-NEAT1), microRNA-124 (miR-124) and lnc-NEAT1/miR-124 axis with disease risk, severity, inflammatory cytokines, and survival of sepsis.Eighty-two patients with sepsis and 82 healthy controls (HCs) were consecutively enrolled. Blood samples were collected for detection of lnc-NEAT1 and miR-124 expressions (using RT-qPCR) and measurement of inflammatory cytokines expressions (by ELISA). Severity and organ failure were assessed by acute physiology and chronic health evaluation II (APACHE II) score and sequential organ failure assessment (SOFA) score, and survival was assessed.Lnc-NEAT1 expression was increased while miR-124 expression was decreased in patients with sepsis compared to HCs, and both of them were able to distinguish patients with sepsis from HCs. For disease condition, lnc-NEAT1 positively associated with APACHE II score, SOFA score, and expressions of C-reactive protein (CRP), procalcitonin, tumor necrosis factor α (TNF-α), and interleukin-1β (IL-1β), whereas miR-124 negatively correlated with APACHE II score, SOFA score and levels of serum creatinine (Scr), CRP, TNF-α, IL-1β, interleukin-6 (IL-6) and interleukin...Continue Reading

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Citations

Feb 6, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Dandan WangJianwei Sun
Apr 3, 2020·Infection & chemotherapy·Mi Hee Kim, Jung Hyun Choi
Oct 13, 2020·Current Opinion in Infectious Diseases·Mildred A Iro, Sudha Priya Soundara Pandi
Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Wei WangTie-Ning Zhang
Jul 10, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xia LvJian-Quan Li

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Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad Prism
SPSS

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