Abstract
Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1), a novel identified long noncoding RNA (lncRNA), has been suggested to serve as oncogene in multiple cancers. However, the functional involvement of OIP5-AS1 in oral squamous cell carcinoma (OSCC) was still unknown. The aims of this study were to investigate the functional role of OIP5-AS1 in OSCC and explore its potential mechanism. We found that OIP5-AS1 was up-regulated in OSCC tissues compared with adjacent non-tumor tissues. Loss-of-function experiments revealed that OIP5-AS1 knockdown significantly inhibited OSCC cell proliferation, migration and invasion in vitro, and retarded tumor growth in vivo. Mechanistically, OIP5-AS1 serves as a competing endogenous RNA of miR-338-3p and modulates the expression of neuropilin1 (NRP1), which has been identified as a downstream target gene of miR-338-3p in OSCC. Moreover, downregulation of miR-338-3p or overexpression of NRP1 partly reversed the inhibitory effect of OIP5-AS1 depletion on cell proliferation, migration and invasion. The current results provide evidences for the role of OIP5-AS1 in promoting OSCC progression by regulating miR-338-3p/NRP1 axis and suggest OIP5-AS1 as a potential therapy target for OSCC.
Citations
Oct 17, 2019·Genes·Lan ChenGuojun Dai
May 27, 2020·Aging·Bo LiJiayu Zhang
Aug 26, 2020·The Kaohsiung Journal of Medical Sciences·Hua-Yun GengGuang-Yao Li
Mar 12, 2020·Journal of Physiology and Biochemistry·Xiangpeng MengZhen Liu
Mar 18, 2020·BMC Ophthalmology·Minwen ZhouMingshui Fu
Aug 10, 2020·Molecular and Cellular Biochemistry·Yunfu YuJifeng Yan
Sep 15, 2020·Cancer Biomarkers : Section a of Disease Markers·Fei TongZhihua Li
May 16, 2020·Cancer Cell International·Yong WangWeiwei Pan
Jun 5, 2020·Cellular Oncology (Dordrecht)·Fei HuangQianming Chen
May 23, 2020·OncoTargets and Therapy·Ling Liu, Shuya Wang
Feb 12, 2020·Gene Therapy·Jianchu WangJian Pu
Dec 29, 2020·Cancer Management and Research·Jing LiHongwu Luo
Feb 12, 2021·OncoTargets and Therapy·Nan ZhangHong Tao
Jan 31, 2021·Life Sciences·Ruihua LiuZhenghua Wang
Apr 26, 2020·Annals of Hepatology·Chen ZhangRong Fang
Feb 26, 2021·BioMed Research International·Jian TangHaitao Xie
Feb 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
Mar 22, 2021·Current Treatment Options in Oncology·Valeria A Ferretti, Ignacio E León
Mar 30, 2021·Frontiers in Cardiovascular Medicine·Minghu ZhaoYu Wu
Dec 10, 2019·Experimental and Molecular Pathology·Soudeh Ghafouri-FardMohammad Taheri
Apr 9, 2021·Cellular & Molecular Biology Letters·Meysam Moghbeli
Jun 3, 2021·International Journal of Molecular Sciences·Cing-Syuan LeiJing-Wen Shih
Jun 17, 2021·Cell Death & Disease·Xiaoping ZhangBo Wu
Aug 7, 2021·Cancer Cell International·Feng QiuWeiliu Qiu
Oct 2, 2021·Bioengineered·Haibo XieYinan Dong