Long noncoding RNA OIP5-AS1 promotes the progression of oral squamous cell carcinoma via regulating miR-338-3p/NRP1 axis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Minghe LiLei Wang

Abstract

Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1), a novel identified long noncoding RNA (lncRNA), has been suggested to serve as oncogene in multiple cancers. However, the functional involvement of OIP5-AS1 in oral squamous cell carcinoma (OSCC) was still unknown. The aims of this study were to investigate the functional role of OIP5-AS1 in OSCC and explore its potential mechanism. We found that OIP5-AS1 was up-regulated in OSCC tissues compared with adjacent non-tumor tissues. Loss-of-function experiments revealed that OIP5-AS1 knockdown significantly inhibited OSCC cell proliferation, migration and invasion in vitro, and retarded tumor growth in vivo. Mechanistically, OIP5-AS1 serves as a competing endogenous RNA of miR-338-3p and modulates the expression of neuropilin1 (NRP1), which has been identified as a downstream target gene of miR-338-3p in OSCC. Moreover, downregulation of miR-338-3p or overexpression of NRP1 partly reversed the inhibitory effect of OIP5-AS1 depletion on cell proliferation, migration and invasion. The current results provide evidences for the role of OIP5-AS1 in promoting OSCC progression by regulating miR-338-3p/NRP1 axis and suggest OIP5-AS1 as a potential therapy target for OSCC.

Citations

Aug 26, 2020·The Kaohsiung Journal of Medical Sciences·Hua-Yun GengGuang-Yao Li
Sep 15, 2020·Cancer Biomarkers : Section a of Disease Markers·Fei TongZhihua Li
Jun 5, 2020·Cellular Oncology (Dordrecht)·Fei HuangQianming Chen
Feb 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
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Apr 9, 2021·Cellular & Molecular Biology Letters·Meysam Moghbeli
Jun 3, 2021·International Journal of Molecular Sciences·Cing-Syuan LeiJing-Wen Shih

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