Abstract
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide, especially in developing countries. Although advances in surgical procedures and targeted medicine have improved the overall survival of patients with HCC, the prognosis is poor. Hence, there is a need to identify novel therapeutic targets for HCC. Here, we report that the expression of RP11-909N17.2, a novel, long, noncoding RNA (lncRNA), is dysregulated in patients with HCC and cell lines. Additionally, this study demonstrated that RP11-909N17.2 facilitates the proliferation and invasion of HCC cells by binding to miRNA-767-3p, a tumor-suppressive microRNA (miRNA). Small integral membrane protein 7 (SMIM7) was identified as the downstream target of miRNA-767-3p. The expression of SMIM7 was upregulated in HCC clinical samples and cell lines. Moreover, SMIM7 was involved in the proliferation and invasion of HCC cells. Furthermore, SMIM7 inhibited the apoptosis of HCC cells, which indicated the oncogenic role of SMIM7 in HCC. The findings of this study suggest that the lncRNA-miRNA-mRNA regulatory axis, which regulates the pathogenesis of HCC, can be a potential novel diagnostic and therapeutic target for HCC.
References
Sep 4, 2008·Cell Research·Xi ChenChen-Yu Zhang
Jun 1, 2011·Oncogene·C BraconiT Patel
Feb 11, 2012·International Journal of Oncology·Mohammad Akbar HossainNam Deuk Kim
Jan 24, 2013·Acta Neuropathologica·Simone KrethFriedrich W Kreth
Apr 9, 2013·Nature Genetics·Ana CvejicCornelis A Albers
Jun 19, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jun LvQian Wang
Dec 3, 2014·Gastroenterology·Chuanhui CaoLi Liu
May 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sheng-xian YuanWei-ping Zhou
Oct 11, 2015·FEBS Letters·Lionel ArnaudBryan A Ballif
Dec 3, 2016·Cell Death & Disease·Xi ChenXiaoren Zhang
Mar 7, 2017·Acta Pharmacologica Sinica·Xiao SunXia Li
Mar 23, 2017·Cell Discovery·Xiaona ChenHuating Wang
Oct 6, 2017·Cell Death & Disease·Lixian YangHongchuan Jin
Nov 25, 2017·Oncology Research·Yi Long WanHai Tao Ma
Feb 17, 2018·Cell Death & Disease·Mei-Hua BaoZhong-Ping Feng
Apr 9, 2018·Biochemical and Biophysical Research Communications·Weidong JiangFangying Yin
Apr 27, 2018·Acta Pharmacologica Sinica·Chen Wang, Qing Jing
May 24, 2018·Cell Death & Disease·Qiang GaoYan Liu
Sep 16, 2018·Acta Pharmacologica Sinica·Mei HanZhi-Wu Han
Dec 7, 2018·Cell Death & Disease·Songman YuXuegong Fan
Dec 20, 2018·EXCLI Journal·Maryam AbbastabarEhsan Khalili
Jan 27, 2019·Cancer Science·Yangjun WuLinhui Liang
Mar 25, 2019·International Journal of Biological Sciences·Xi ChenYingying Lin
Apr 21, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing LiXuehao Wang