Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Qingchun LuTao Ren

Abstract

Long noncoding RNAs participate in the progression and initiation of non-small cell lung cancer (NSCLC), although the mechanism remains unknown. The lncRNA identified as small nucleolar RNA host gene 1 ( SNHG1) is a novel lncRNA that is increased in multiple human cancers; however, the regulatory mechanism requires further investigation. In this study, we discovered that SNHG1 was markedly up-regulated in NSCLC tissues and cells and that SNHG1 silencing decreased tumor volumes. Moreover, we explored its regulatory mechanism and found that SNHG1 directly bound to microRNA (miRNA)-145-5p, isolating miR-145-5p from its target gene MTDH. Inhibition of SNHG1 suppressed NSCLC cell viability, proliferation, migration, and invasion in vitro, but its effect was rescued by miR-145-5p inhibition. These results demonstrate that SNHG1 contributes to NSCLC progression by modulating the miR-145-5p/ MTDH axis, and it could potentially be a therapeutic target as well as a diagnostic marker.-Lu, Q., Shan, S., Li, Y., Zhu, D., Jin, W., Ren, T. Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p.

References

Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jun 19, 2010·Science·Demián CazallaJoan A Steitz
Oct 13, 2010·Current Biology : CB·Margaret S Ebert, Phillip A Sharp
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Byoung Kwon YooDevanand Sarkar
Mar 19, 2013·Cell·Pedro J Batista, Howard Y Chang
Feb 14, 2014·Frontiers in Genetics·Reena V Kartha, Subbaya Subramanian
Sep 23, 2014·Methods in Molecular Biology·Murugan SubramanianAshish Lal
Nov 28, 2014·Medical Oncology·Mingzhi WangYongmei Chang
Jun 11, 2015·PloS One·Feng YuPaul M Neilsen
Sep 2, 2015·Journal of Cancer Research and Therapeutics·Tao WuZhijun Zhao
May 31, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Haibo HuJun Zhao
Nov 20, 2016·Frontiers in Genetics·Jinpao HouS C Cesar Wong
Mar 2, 2017·The Journal of Clinical Investigation·Brian D AdamsFrank J Slack
Apr 13, 2017·Biochemical and Biophysical Research Communications·Jianping LiJuan Wang
May 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiang WangFeng Zhi
Jun 13, 2017·Oncogene·W-X PengY-Y Mo

❮ Previous
Next ❯

Citations

Sep 5, 2020·Journal of Cellular and Molecular Medicine·Wei XiangGuosong Jiang
Jul 8, 2020·Non-coding RNA·Lucy GinnMichela Garofalo
Sep 7, 2018·Journal of Experimental & Clinical Cancer Research : CR·Sen-Mao LiJia Hu
Mar 17, 2020·Cancer Biomarkers : Section a of Disease Markers·Rui Liang, Youjia Tang
Aug 11, 2020·Cancer Cell International·Haiyan HanXuejie Liu
May 29, 2018·Environmental Science and Pollution Research International·Zhibin ZuoQibao Wang
Apr 23, 2020·Frontiers in Oncology·Alina-Andreea ZimtaIoana Berindan-Neagoe
Feb 14, 2019·Journal of Experimental & Clinical Cancer Research : CR·Peng LuoBaolong Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.