Abstract
Long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of various cancers, including laryngeal squamous cell carcinoma (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been identified as an oncogene in various cancers. However, the functional role and the regulatory mechanism of SOX2-OT in LSCC remains unclear. In this study, we found that SOX2-OT expression was increased and negatively correlated with PTEN expression in LSCC tissues. Furthermore, SOX2-OT overexpression promoted LSCC cell proliferation, migration, invasion, and suppressed cell apoptosis in vitro, as well as facilitated the in vivo tumorigenicity. By contrast, SOX2-OT silencing exerted the opposite effect. Mechanically, SOX2-OT interacted with EZH2 and recruited EZH2 to induce H3K27me3 and epigenetically inhibited PTEN expression in LSCC cells. Additionally, EZH2 silencing and PTEN overexpression significantly abrogated the SOX2-OT overexpression-mediated promotion of LSCC cell malignant behavior. Collectively, our findings demonstrate that SOX2-OT inhibits PTEN expression to facilitate LSCC development through EZH2-mediated H3K27me3. © 2019 IUBMB Life, 71(9):1230-1239, 2019.
References
Jan 22, 2002·Cancer Genetics and Cytogenetics·Micaela PoetschBritta Kleist
Sep 28, 2002·Science·Ru CaoYi Zhang
Jul 27, 2012·The Journal of Clinical Investigation·S Michael Rothenberg, Leif W Ellisen
Sep 22, 2012·Biochemical and Biophysical Research Communications·Xin LiXin Wang
Nov 13, 2012·The American Journal of Pathology·Dandan LiMing Liu
Dec 15, 2015·Gene·Wenfa YuRong Lian
Aug 18, 2016·Oncotarget·John Zeng-Hong LiThian-Sze Wong
Sep 18, 2016·Biochemical and Biophysical Research Communications·HuaNan LuoXiaoYong Ren
Dec 17, 2016·Cancer Biomarkers : Section a of Disease Markers·Zhao-Yang YangHai Zeng
Dec 30, 2016·PloS One·Ling FengJugao Fang
Oct 1, 2017·Experimental and Therapeutic Medicine·Fengzhi SiChunli Wang
Jan 18, 2018·Journal of Hematology & Oncology·Lu GanWeijian Guo
Feb 6, 2018·Cell·Changliang LiuPascal S Kaeser
Jun 1, 2018·Cancer Cell International·Yuanyuan WuYun Bai
Jul 22, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy J JaromeFarah D Lubin
Sep 15, 2018·OncoTargets and Therapy·Kewei ZhangYing Tang
Sep 16, 2018·Journal of Experimental & Clinical Cancer Research : CR·Wang LiLin Huang
Sep 28, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zhonghua ZhangDapeng Lei
Nov 22, 2018·Molecular Cancer·Ru WangJugao Fang
Dec 7, 2018·Biochemical and Biophysical Research Communications·Yidi HanXiaoping Fan
Dec 12, 2018·Journal of Cellular Physiology·Changhui GaoQiang Xu
Citations
Jun 12, 2019·IUBMB Life·Zhao ZhihuaGuozhong Jiang
Sep 4, 2019·IUBMB Life·Liang ShaoYuan Qin
Apr 9, 2020·Experimental and Therapeutic Medicine·Guang LiJingwu Sun
Sep 12, 2020·Molecular Biology Reports·Jiayu ZhaoHongjiang He
Sep 29, 2020·OncoTargets and Therapy·Bo YuanJinjian Yang
Aug 28, 2020·Frontiers in Pharmacology·Wei LiXuqiang Nie
Dec 10, 2020·BioMed Research International·Pu-Yu LiDao-Yin Dong
Jan 13, 2021·Molecular Oncology·Abril Marcela Herrera-SolorioFederico Ávila-Moreno
Dec 10, 2019·Experimental and Molecular Pathology·Soudeh Ghafouri-FardMohammad Taheri
Apr 6, 2021·Frontiers in Oncology·Xiuchao GengQiang Li
Jul 30, 2021·Frontiers in Oncology·Hongfeng ZhaoLiwen Sun
Jul 30, 2021·The Tohoku Journal of Experimental Medicine·Jiahong TuJie Zhang
Aug 27, 2021·Cell Cycle·Tianyi WuBoyu Yu
Jan 26, 2020·Molecular Therapy. Nucleic Acids·Zheng-Tian LiXue-Ying Sun
Jan 9, 2022·Cellular and Molecular Life Sciences : CMLS·Wenwen ZhangXiaoxiang Guan