Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1

Proceedings of the National Academy of Sciences of the United States of America
Kenzui TaniueTetsu Akiyama

Abstract

Many long noncoding RNAs (lncRNAs) are reported to be dysregulated in human cancers and play critical roles in tumor development and progression. Furthermore, it has been reported that many lncRNAs regulate gene expression by recruiting chromatin remodeling complexes to specific genomic loci or by controlling transcriptional or posttranscriptional processes. Here we show that an lncRNA termed UPAT [ubiquitin-like plant homeodomain (PHD) and really interesting new gene (RING) finger domain-containing protein 1 (UHRF1) Protein Associated Transcript] is required for the survival and tumorigenicity of colorectal cancer cells. UPAT interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its β-transducin repeat-containing protein (TrCP)-mediated ubiquitination. Furthermore, we demonstrate that UHRF1 up-regulates Stearoyl-CoA desaturase 1 and Sprouty 4, which are required for the survival of colon tumor cells. Our study provides evidence for an lncRNA that regulates protein ubiquitination and degradation and thereby plays a critical role in the survival and tumorigenicity of tumor cells. Our results suggest that UPAT and UHRF1 may be promising molecular targets for the therapy of colon cancer.

References

Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiao-Song WangWei-Feng Chen
Feb 27, 2007·Cell·Aaron D GoldbergEmily Bernstein
Jan 22, 2008·Nature Immunology·Elaine Dzierzak, Nancy A Speck
May 27, 2008·Nature Reviews. Cancer·David Frescas, Michele Pagano
Oct 8, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Paulo P Amaral, John S Mattick
Nov 11, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Tim R MercerJohn S Mattick
Jun 6, 2009·British Journal of Cancer·M UnokiR Hamamoto
Jun 3, 2010·British Journal of Cancer·M UnokiY Nakamura
Jan 11, 2011·The Biochemical Journal·Amy L TienChinweike Ukomadu
Jan 27, 2011·Journal of Cellular Biochemistry·Weihua QinFabio Spada
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Honghui MaYang Shi
Jun 6, 2012·Annual Review of Biochemistry·John L Rinn, Howard Y Chang
Oct 2, 2012·Nature Structural & Molecular Biology·Scott B RothbartBrian D Strahl
Dec 15, 2012·Science·Jeannie T Lee
Jan 9, 2013·Molecular and Cellular Biology·Hao ChenYang Shi
Feb 20, 2013·Scientific Reports·Satoshi YanagidaTetsu Akiyama
Mar 19, 2013·Cell·Pedro J Batista, Howard Y Chang
Jul 6, 2013·Cell·Igor Ulitsky, David P Bartel
Dec 7, 2013·Cell Death & Disease·A NotoR Mancini
Dec 12, 2013·Nature Communications·Je-Hyun YoonMyriam Gorospe
Jan 29, 2014·International Journal of Cancer. Journal International Du Cancer·Anna P SokolenkoEvgeny N Imyanitov
Apr 1, 2014·Cell·Thomas R Cech, Joan A Steitz
Apr 20, 2014·Cancer Metastasis Reviews·Samar Masoumi-MoghaddamDavid Lawson Morris
Jun 7, 2014·Cell Stem Cell·Ryan A Flynn, Howard Y Chang

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Citations

Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kenzui TaniueTetsu Akiyama
Dec 12, 2017·Journal of Cellular Physiology·Qiong WuHaijian Zhao
Feb 23, 2018·The Journal of Biological Chemistry·Yung-Chun WangShi-You Chen
Jan 22, 2017·Oncotarget·Jian LuoQiang Qu
Jan 26, 2020·Pathogens and Disease·Narges DastmalchiReza Safaralizadeh
Mar 23, 2019·Yonsei Medical Journal·Xiaohuan TangJingjing Liu
May 31, 2019·International Journal of Molecular Sciences·Lei ZhangZekun Guo
Jul 31, 2019·JNCI Cancer Spectrum·Divya SahuHsuan-Cheng Huang
Jan 8, 2020·In Vitro Cellular & Developmental Biology. Animal·Yang YuDong-Sheng Zhou
Sep 25, 2020·Asia-Pacific Journal of Clinical Oncology·Arash PoursheikhaniMohammad Amin Kerachian
Sep 29, 2019·World Journal of Gastroenterology : WJG·Orsolya GalambBéla Molnár
Oct 11, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Atsuko MikiKunihiro Ohta
Apr 17, 2020·Molecular Cancer·Zhao HuangCanhua Huang
May 8, 2019·Applied Microbiology and Biotechnology·Chit TamTzi Bun Ng
Oct 7, 2020·The FEBS Journal·Yanli BiYongchao Zhao
Nov 29, 2020·Molecular Cancer·Sian Chen, Xian Shen
Feb 10, 2021·Non-coding RNA·Kenzui Taniue, Nobuyoshi Akimitsu

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