Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer

International Journal of Molecular Medicine
Li FanTingting Yao

Abstract

Cervical cancer is one of the most common types of female malignant tumor. It is well established that radiotherapy (RT) is the first‑line treatment of cervical cancer; however, radioresistance is a substantial obstacle to cervical cancer RT. At present, the mechanism underlying radioresistance remains unclear. Emerging evidence has demonstrated that long non‑coding RNAs (lncRNAs) function as crucial regulators of diverse cancers. Aerobic glycolysis, which is a common phenomenon in cancer cells, is associated with various biological functions, including radioresistance. To the best of our knowledge, the present study is the first to explore the role of the lncRNA urothelial cancer associated 1 (UCA1) in cervical cancer radioresistance. In the present study, irradiation was used to establish irradiation‑resistant (IRR) cells, after which a clonogenic survival assay was used to validate radioresistance, reverse transcription‑quantitative polymerase chain reaction was used to evaluate the expression levels of UCA1 and western blotting was conducted to detect the expression levels of glycolysis‑related proteins. In addition, a glucose/lactate assay kit was used to evaluate glucose/lactate concentrations and cells were transfected w...Continue Reading

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Citations

Apr 25, 2020·Pathogens·Surendra Sharma, Karl Munger
Mar 4, 2020·Molecular Cancer·Xinyi ZhangYongguang Tao
Mar 21, 2020·Frontiers in Oncology·Wan-Chun LiKuo-Wei Chang
Dec 19, 2019·Frontiers in Oncology·Wei LuJie Ma
Oct 31, 2020·Frontiers in Oncology·Shuhei KamadaSatoshi Inoue
Oct 31, 2020·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
Mar 4, 2021·Cancers·Amar BalihodzicMartin Pichler

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