Long Noncoding RNA XIST Regulates miR-137-EZH2 Axis to Promote Tumor Metastasis in Colorectal Cancer.

Oncology Research
Xingxiang LiuDong Hua

Abstract

We aimed to investigate the significant role of long noncoding RNA X inactive specific transcript (XIST) in regulating tumor metastasis in colorectal cancer (CRC), as well as its possible mechanism. Expression of lncRNA XIST in CRC tissues and CRC cells was detected. CRC cells were transfected with pc-XIST, blank control si-XIST, or si-control, and then the effects of lncRNA XIST on CRC cell migration and invasion were investigated, along with the interaction between lncRNA XIST and miR-137. lncRNA XIST was upregulated in CRC tissues. Compared with HT29 cells that had low metastatic potential, XIST was markedly more highly expressed in LoVo cells that had a higher metastatic potential. Overexpression of XIST promoted the migratory and invasive potential of HT29 cells, while knockdown of XIST inhibited the migratory and invasive potential of LoVo cells. Moreover, epithelial-mesenchymal transition (EMT) markers, including E-cadherin, N-cadherin, and vimentin, exhibited corresponding expression changes. In addition, miR-137 was inhibited by XIST, and inhibition of miR-137 could reverse the effects of knockdown of XIST on the migratory and invasive potential of LoVo cells. Furthermore, enhancer of zeste homolog 2 (EZH2) was confirm...Continue Reading

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Citations

Sep 25, 2020·Asia-Pacific Journal of Clinical Oncology·Arash PoursheikhaniMohammad Amin Kerachian
Aug 23, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Wei LiZhaoling Cheng
Aug 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chunmei HuChunling Xu
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Soudeh Ghafouri-FardSeyed Ali Mousavinejad
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Wenlun WangLingyun Zhu
Jul 26, 2021·European Journal of Pharmacology·Chunyuan TangLushan Yu
Aug 13, 2021·Cell Death Discovery·Yan LiuZuozhang Yang
Jun 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hong ZhuLei Wang

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Methods Mentioned

BETA
surgical resections
transfection
Assay
PCR

Software Mentioned

TargetScan
SPSS

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