Abstract
We aimed to investigate the significant role of long noncoding RNA X inactive specific transcript (XIST) in regulating tumor metastasis in colorectal cancer (CRC), as well as its possible mechanism. Expression of lncRNA XIST in CRC tissues and CRC cells was detected. CRC cells were transfected with pc-XIST, blank control si-XIST, or si-control, and then the effects of lncRNA XIST on CRC cell migration and invasion were investigated, along with the interaction between lncRNA XIST and miR-137. lncRNA XIST was upregulated in CRC tissues. Compared with HT29 cells that had low metastatic potential, XIST was markedly more highly expressed in LoVo cells that had a higher metastatic potential. Overexpression of XIST promoted the migratory and invasive potential of HT29 cells, while knockdown of XIST inhibited the migratory and invasive potential of LoVo cells. Moreover, epithelial-mesenchymal transition (EMT) markers, including E-cadherin, N-cadherin, and vimentin, exhibited corresponding expression changes. In addition, miR-137 was inhibited by XIST, and inhibition of miR-137 could reverse the effects of knockdown of XIST on the migratory and invasive potential of LoVo cells. Furthermore, enhancer of zeste homolog 2 (EZH2) was confirm...Continue Reading
References
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Oct 6, 2010·Gut·Colin C Pritchard, William M Grady
Feb 24, 2011·Molecular Cancer·Sandra Kraljevic PavelicKresimir Pavelic
Jun 6, 2012·RNA Biology·Tony Gutschner, Sven Diederichs
Sep 22, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peng Qi, Xiang Du
Nov 28, 2012·Lancet·Axel GrotheyUNKNOWN CORRECT Study Group
Dec 4, 2013·Nature Reviews. Genetics·Alessandro Fatica, Irene Bozzoni
Mar 4, 2014·Carcinogenesis·Miroslav SvobodaPavel Vodicka
Jul 1, 2014·Pathology·Yu HanYu-xian Bai
Jul 16, 2014·British Journal of Cancer·Q JiQ Li
Oct 20, 2014·Journal of Cancer Research and Clinical Oncology·Yan-Long LiuYan-Mei Yang
Mar 11, 2015·Cancer Letters·Dong HanXu Gao
Oct 28, 2015·Oncotarget·Nithyananda ThorenoorOndrej Slaby
Jan 10, 2016·Molecular Cancer Research : MCR·Masazumi SakaguchiYoshiharu Sakai
Feb 10, 2016·Journal of Translational Medicine·Junfeng SunJiaxiang Wang
Feb 13, 2016·Oncotarget·Hiroyoshi KuriharaKatsuhiko Nosho
May 18, 2016·Molecular Cancer·Peng QiXiang Du
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Jul 28, 2016·Gene·Peng SongXu-Hong Zhou
Sep 7, 2016·Journal of Experimental & Clinical Cancer Research : CR·Peixin DongNoriaki Sakuragi
Sep 14, 2016·Journal of Experimental & Clinical Cancer Research : CR·Dong-Liang ChenRui-Hua Xu
Dec 3, 2016·Oncotarget·Lei MaYingjie Jiang
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 14, 2017·Oncogenesis·H YuY Liu
Apr 28, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Haoyou WangShun Xu
Jun 15, 2017·Cancer Letters·Tzu-Hua ChangJin-Yuan Shih
Aug 25, 2017·Cell Death & Disease·Dong-Liang ChenRui-Hua Xu
Sep 5, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yaoyao XiongLin Qi
Citations
Jan 19, 2019·Journal of Cellular Physiology·Aihua LiuHang Lu
Mar 12, 2020·Cell Biology International·Yonghui LiShujie Cheng
Jul 31, 2020·Cancer Biology & Therapy·Stephen J O'BrienSusan Galandiuk
Feb 10, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Yafeng SunXianhong Zhang
Jul 17, 2019·Journal of Cellular Physiology·Atefeh TalebiAbolfazl Akbari
Jun 15, 2019·International Journal of Molecular Medicine·Tao WangZhonghai Zhao
Sep 25, 2020·Asia-Pacific Journal of Clinical Oncology·Arash PoursheikhaniMohammad Amin Kerachian
Mar 27, 2020·Frontiers in Medicine·Shuyuan LiXipeng Zhang
Mar 13, 2019·Cancer Cell International·Xing ChenMeifen Wang
Dec 11, 2020·Cancer Cell International·Nan WangXian-Li He
Apr 6, 2020·Archives of Oral Biology·Xinzhu LiBuling Wu
Aug 23, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Wei LiZhaoling Cheng
Jan 3, 2021·Cancer Biomarkers : Section a of Disease Markers·Hailun ZhengQiangwu Wang
Nov 17, 2020·Frontiers in Genetics·Weiyu FengJing Zhuang
Feb 13, 2021·Cancer Letters·Yufei YangAjay Goel
Aug 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chunmei HuChunling Xu
Oct 17, 2020·Cell Cycle·Juntong WangDongchun Wang
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Soudeh Ghafouri-FardSeyed Ali Mousavinejad
Jul 6, 2021·Frontiers in Molecular Biosciences·Changjun ZhengLei Zhong
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Wenlun WangLingyun Zhu
Jul 26, 2021·European Journal of Pharmacology·Chunyuan TangLushan Yu
Jun 16, 2021·Carcinogenesis·Kaiyi TaoWeiMin Mao
Aug 13, 2021·Cell Death Discovery·Yan LiuZuozhang Yang
Sep 3, 2021·Andrologia·Qi LiJianming Pu
Sep 24, 2021·Molecular Therapy Oncolytics·Zhengwei ChenYijun Mei
Jun 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hong ZhuLei Wang
Nov 30, 2021·Gynecologic and Obstetric Investigation·Yanmei Li, Lei Liu