Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases.

Biomolecules
Valeria LoddeMaria Laura Idda

Abstract

Immune responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled, autoimmune diseases can occur. Autoimmune diseases (ADs) are a family of disorders characterized by the body's immune response being directed against its own tissues, with consequent chronic inflammation and tissue damage. Despite enormous efforts to identify new drug targets and develop new therapies to prevent and ameliorate AD symptoms, no definitive solutions are available today. Additionally, while substantial progress has been made in drug development for some ADs, most treatments only ameliorate symptoms and, in general, ADs are still incurable. Hundreds of genetic loci have been identified and associated with ADs by genome-wide association studies. However, the whole list of molecular factors that contribute to AD pathogenesis is still unknown. Noncoding (nc)RNAs, such as microRNAs, circular (circ)RNAs, and long noncoding (lnc)RNAs, regulate gene expression at different levels in various diseases, including ADs, and serve as potential drug targets as well as biomarkers for disease progression and response to therapy. In this review, we will focus on the potential roles...Continue Reading

References

Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·M O KurrerJ D Katz
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Jul 31, 2001·Lancet·M A Atkinson, G S Eisenbarth
Aug 30, 2001·Nature Immunology·A Wandstrat, E Wakeland
Mar 7, 2002·Arthritis Research·Martinus A M van BoekelWalther J van Venrooij
Nov 28, 2002·Diabetes·Edwin A M Gale
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emily C BaechlerTimothy W Behrens
Oct 27, 2004·Seminars in Arthritis and Rheumatism·Yaniv ShererYehuda Shoenfeld
Nov 22, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Harry E Prince
May 3, 2006·Human Molecular Genetics·John S Mattick, Igor V Makunin
Sep 22, 2007·Lancet Neurology·David H Miller, Siobhan M Leary
Oct 2, 2007·Journal of Autoimmunity·Karl S LangMike Recher
Jan 8, 2008·Autoimmunity·Craig E Taplin, Jennifer M Barker
Feb 19, 2008·Nature Medicine·Ingunn M StromnesJoan M Goverman
Oct 8, 2008·Journal of Autoimmunity·Yehuda ShoenfeldM Eric Gershwin
Jan 9, 2009·Clinical and Experimental Immunology·A WillcoxN G Morgan
Apr 3, 2009·Brain : a Journal of Neurology·Josa M FrischerHans Lassmann
Apr 14, 2009·Current Opinion in Immunology·Adewole S AdamsonJohn J O'Shea
May 16, 2009·Arthritis Research & Therapy·Marian Suarez-GestalUNKNOWN European Consortium of SLE DNA Collections
May 19, 2009·Current Opinion in Cell Biology·Christopher A Brosnan, Olivier Voinnet
Aug 1, 2009·Arthritis and Rheumatism·Angela MidgleyMichael W Beresford
Oct 13, 2009·Diabetes, Obesity & Metabolism·K Fujimoto, K S Polonsky
Nov 26, 2009·Brain : a Journal of Neurology·Verena Brucklacher-WaldertEva Tolosa
Jan 26, 2010·Nature Reviews. Immunology·Ryan M O'ConnellDavid Baltimore
Jan 30, 2010·Arthritis and Rheumatism·Heidi KokkonenSolbritt Rantapää Dahlqvist
Aug 9, 2011·Annals of the Rheumatic Diseases·Karim RazaChristopher D Buckley
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Dec 2, 2011·The New England Journal of Medicine·George C Tsokos
Aug 24, 2012·Molecular Endocrinology·Gregory M KuMichael T McManus
Sep 26, 2012·Nature Reviews. Neurology·Hans LassmannDon Mahad
Oct 23, 2012·Frontiers in Genetics·Zhipeng Qu, David L Adelson
Dec 21, 2012·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Christian BuchbenderAxel Scherer
Jan 24, 2013·Arthritis Research & Therapy·Nicola BizzaroUNKNOWN Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA Group)
May 8, 2013·Trends in Endocrinology and Metabolism : TEM·Scott A Soleimanpour, Doris A Stoffers
Jul 23, 2013·Nature Neuroscience·Veronique E MironCharles Ffrench-Constant
Dec 20, 2013·Clinical Reviews in Allergy & Immunology·Yu LiuQianjin Lu
Apr 12, 2014·Clinical and Experimental Medicine·Jinsoo SongEun-Jung Jin
May 6, 2014·PloS One·Giulio DisantoGavin Giovannoni
May 9, 2014·Nature Biotechnology·William R Jeck, Norman E Sharpless
May 21, 2014·Nature Immunology·Martin TurnerElena Vigorito

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Citations

Feb 7, 2021·International Journal of Molecular Sciences·Flora Brozzi, Romano Regazzi
May 21, 2021·Transplant Immunology·Yao TengQiuling Wu
Jun 29, 2021·Frontiers in Cardiovascular Medicine·Wen-Chu YeGuo-Jun Zhao
Sep 11, 2021·Scientific Reports·Katarzyna Durlik-PopińskaWiesław Kaca
Oct 16, 2021·Wiley Interdisciplinary Reviews. RNA·Valeria LoddeMaria Laura Idda
Oct 30, 2021·Experimental Dermatology·Nesreen M Abo RaiaTalal A Abd Elrahim

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Datasets Mentioned

BETA
AF064858.11
AF064858.8

Methods Mentioned

BETA
PCR
histone acetylation

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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