Long noncoding RNAs and the regulation of innate immunity and host-virus interactions

Journal of Leukocyte Biology
Megha BasavappaJorge Henao-Mejia

Abstract

Immune responses are both pathogen and cell type-specific. The innate arm of immunity is characterized by rapid intracellular signaling cascades resulting in the production of hundreds of antimicrobial effectors that protect the host organism. Long noncoding RNAs have been shown to operate as potent modulators of both RNA and protein function throughout cell biology. Emerging data suggest that this is also true within innate immunity. LncRNAs have been shown to regulate both innate immune cell identity and the transcription of gene expression programs critical for innate immune responses. Here, we review the diverse roles of lncRNAs within innate defense with a specific emphasis on host-virus interactions.

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Citations

Jun 17, 2020·Emerging Microbes & Infections·Jing Wang, Shan Cen
Jul 21, 2020·Immunotherapy·Luka de VosAlina Franzen
Jun 26, 2020·Seminars in Cell & Developmental Biology·Tim Vierbuchen, Katherine A Fitzgerald
Jan 8, 2021·Annals of the Rheumatic Diseases·Akari SuzukiKazuhiko Yamamoto
Jul 23, 2021·Genes & Diseases·FengXia GaoAiShun Jin

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