Long noncoding RNAs in the pathogenesis of diabetic kidney disease: implications for novel therapeutic strategies

Personalized Medicine
Fatjon LetiJohanna K DiStefano

Abstract

Diabetic kidney disease is a progressive disorder that develops secondary to diabetes. Current strategies for the clinical management of the disease can delay its onset and prevent progression, yet a significant proportion of patients still develop renal failure. The need for more advanced pharmaceuticals is therefore critical for improved treatment strategies. Recent studies support a role for long noncoding RNAs (lncRNAs) in the pathogenesis of human disease. Here we review recent experimental results linking lncRNAs with diabetic kidney disease. A better understanding of the regulatory role that lncRNAs play in the development of diabetic kidney disease may lead to identification of novel targets for therapeutic intervention.

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Citations

Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lei ZhangYunfeng Zhu
May 1, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Koen E GroenewegRoel Bijkerk
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Oct 22, 2019·Biochemical and Biophysical Research Communications·Huimeng QiQiang Liu
Jan 26, 2021·Toxicology Letters·Xiaozhuan LiuZengli Yu
Jun 2, 2021·Journal of Leukocyte Biology·Dongdong MengGuijun Qin
Aug 10, 2020·Archives of Biochemistry and Biophysics·Hongtao ChenJun Zhou
Oct 17, 2021·Diabetology & Metabolic Syndrome·Li ZhaoHualing Ruan

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Methods Mentioned

BETA
antisense oligonucleotides

Software Mentioned

GapmeRs

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