Long noncoding RNAs: new insights in modulating mammalian spermatogenesis

Journal of Animal Science and Biotechnology
Bahlibi Weldegebriall SahluHuabin Zhu

Abstract

Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs (lncRNAs) and highly regulated and specific gene expression. LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored. Only a few of them have post-meiotic; however, lncRNAs are involved in many cellular biological processes. The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies. This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis.

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Citations

Nov 1, 2020·Reproductive Biology and Endocrinology : RB&E·Meghali Joshi, Singh Rajender
Jan 28, 2021·Journal of Biomolecular Structure & Dynamics·Soudabeh SabetianClaudia Cava
Jan 15, 2021·International Journal of Molecular Sciences·Xiaoning ZhangXuhui Zeng
Jul 10, 2021·Trends in Genetics : TIG·Nicole A Leypold, Michael R Speicher

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Methods Mentioned

BETA
immunoprecipitation
gene knock out
cDNA library
RNA-Seq

Software Mentioned

NONCODE
QRNA
EvoFOLD
EVlncRNA
PhyloCSF
RNAcentral
RNAz

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