Long noncoding RNAs: new insights into non-small cell lung cancer biology, diagnosis and therapy

Medical Oncology
Biagio RicciutiGiulio Metro

Abstract

Recent advances in tiling array and high throughput analyses revealed that at least 87.3 % of the human genome is actively transcribed, though <3 % of the human genome encodes proteins. This unexpected truth suggests that most of the transcriptome is constituted by noncoding RNA. Among them, high-resolution microarray and massively parallel sequencing analyses identified long noncoding RNAs (lncRNAs) as nonprotein-coding transcripts. lncRNAs are largely polyadenylated and >200 nucleotides in length transcripts, involved in gene expression through epigenetic and transcriptional regulation, splicing, imprinting and subcellular transport. Although lncRNAs functions are largely uncharacterized, accumulating data indicate that they are involved in fundamental biological functions. Conversely, their dysregulation has increasingly been recognized to contribute to the development and progression of several human malignancies, especially lung cancer, which represents the leading cause of cancer-related deaths worldwide. We conducted a comprehensive review of the published literature focusing on lncRNAs function and disruption in nonsmall cell lung cancer biology, also highlighting their value as biomarkers and potential therapeutic targ...Continue Reading

References

Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Xun ZhangAnne Klibanski
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Peter VajkoczyAxel Ullrich
Jan 11, 2007·Genes & Development·Kannanganattu V Prasanth, David L Spector
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
Jun 16, 2007·The Journal of Biological Chemistry·Yunli ZhouAnne Klibanski
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice T ShawA John Iafrate
Mar 12, 2011·Nature Reviews. Urology·George Leighton LeeShiv Srivastava
Mar 15, 2011·International Journal of Cancer. Journal International Du Cancer·Leonidas BenetatosEleftheria Hatzimichael
May 12, 2011·Cancer Research·Divya KhaitanRanjan J Perera
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Sep 20, 2011·Molecular Cell·Kevin C Wang, Howard Y Chang
Nov 18, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lars Henning SchmidtCarsten Muller-Tidow
Jan 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristin BergethonA John Iafrate
Jan 12, 2012·Journal of Cellular Biochemistry·Pengjun WangPiyun Sun
Sep 8, 2012·Nature·Sarah DjebaliThomas R Gingeras
Sep 22, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peng Qi, Xiang Du
Nov 24, 2012·Nucleic Acids Research·Geng ChenQinghua Cui
Mar 27, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tony GutschnerSven Diederichs
Apr 10, 2013·Biochemical and Biophysical Research Communications·Yunhee LeeSemi Kim
May 15, 2013·Journal of Hematology & Oncology·Yan ZhuangBin Shan
May 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Philip ThaiReen Wu
Jun 12, 2013·The International Journal of Biochemistry & Cell Biology·Chi Han Li, Yangchao Chen

❮ Previous
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Citations

Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shifeng ChenChengming Sun
Jul 21, 2016·Seminars in Cell & Developmental Biology·Sophia J HäfnerAnders H Lund
Nov 20, 2016·Journal of Biochemical and Molecular Toxicology·Haiqiang XieYinxue Xu
Mar 24, 2017·International Journal of Cancer. Journal International Du Cancer·Jing DongHongbing Shen
Oct 27, 2017·Oncotarget·Yuqing HeWeiming He
Oct 6, 2017·Oncotarget·Yuting ZhanSongqing Fan
Aug 3, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Hong Yue LiuJin Long Liu
Feb 6, 2020·Journal of Clinical Laboratory Analysis·Yinyin ZhuQi Liao
Dec 4, 2019·Bioscience, Biotechnology, and Biochemistry·Xiaoming MaoHua Zhou
Oct 22, 2019·Frontiers in Oncology·Mercedes BermúdezRosalío Ramos-Payán
Aug 25, 2020·Cancer Biomarkers : Section a of Disease Markers·Jia-Yi SongRui Wang
Jan 27, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Fayyaz AhmedTayyab Husnain
Jul 22, 2018·Biochemical and Biophysical Research Communications·Bing ZhangYu-Xin Lv
May 6, 2019·Biochemical and Biophysical Research Communications·Cuixia BianHuirong Gai

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