Long noncoding RNAs: novel players in colorectal cancer

Cancer Letters
Dong HanXu Gao

Abstract

Colorectal cancer (CRC) is the most common type of cancer in the world. Despite its commonness, the underlying mechanism of CRC is not completely understood. Long noncoding RNAs (lncRNAs) have received increased attention with the development of whole genome and transcriptome sequencing technologies. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These lncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. In this review, we highlight recent findings of emerging roles for lncRNAs in CRC and discuss rapid translational lncRNA research for clinical application in diagnosis, prognosis and potential treatment.

References

Jul 9, 1992·International Journal of Cancer. Journal International Du Cancer·A BorgH Sigurdsson
Mar 1, 1989·Molecular and Cellular Biology·E Shtivelman, J M Bishop
Aug 11, 2004·Urology·Yves FradetCamille Chypre
Nov 3, 2004·The Journal of Gene Medicine·Patricia OhanaAbraham Hochberg
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Dec 17, 2005·Cancer Research·Atsushi Kaneda, Andrew P Feinberg
Jan 24, 2007·RNA·Xuezhong Cai, Bryan R Cullen
May 16, 2007·Journal of Cellular Physiology·Letizia CarramusaSalvatore Feo
Jul 10, 2007·Nature Genetics·Christopher A HaimanBrian E Henderson
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yinghui GuanJoe W Gray
Mar 21, 2008·Journal of Cell Science·Mirna Mourtada-MaarabouniGwyn T Williams
Jun 26, 2008·Journal of the National Cancer Institute·Maya GhoussainiUNKNOWN UK ProtecT Study Collaborators
Oct 3, 2008·Nucleic Acids Research·Marcel E DingerJohn S Mattick
Oct 25, 2008·Nucleic Acids Research·Toutai MituyamaKiyoshi Asai
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Feb 15, 2011·Biochemical and Biophysical Research Communications·Lei YouYu-Pei Zhao
May 7, 2011·International Journal of Cancer. Journal International Du Cancer·Aviram NissanAli Osmay Gure
Aug 30, 2011·International Journal of Oncology·Vladimir SorinAbraham Czerniak
Sep 20, 2011·Molecular Cell·Kevin C Wang, Howard Y Chang
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
Nov 24, 2011·The Journal of Biological Chemistry·Anthony M BarsottiCarol Prives
Dec 3, 2011·Nucleic Acids Research·Dechao BuYi Zhao
Mar 7, 2012·Journal of Molecular Endocrinology·Yunli ZhouAnne Klibanski

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Citations

Aug 27, 2015·International Journal of Molecular Sciences·Jun WangZhen-Ning Wang
Dec 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yifan LianKeming Wang
Jun 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Feng WangLin Chen
Jul 5, 2016·Virus Research·Linxi ShiNing Li
Aug 25, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuan LiChangzhi Huang
Dec 3, 2016·Acta Pharmacologica Sinica·Yi-Zhong Hu, Ling Gao
Jul 20, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianguang JinYanhui Yang
May 9, 2018·Journal of Cellular Biochemistry·Gui-Qing JiaZhe-Yu Chen
Aug 27, 2018·Journal of Cellular Biochemistry·Zheying ZhangHaijun Wang
May 29, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Wei ZongMing Cui
Feb 13, 2019·International Journal of Molecular Sciences·Gabriela Marisol Cruz-MirandaSilvia Jiménez-Morales
Jul 25, 2019·Journal of Cellular Physiology·Zilong YouShouping Xu
Jan 21, 2020·Journal of Cellular Physiology·Zilong YouDa Pang
Apr 19, 2017·Oncotarget·He LiHong-Hao Zhou

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