Long noncoding RNAs: Novel regulators of virus-host interactions

Reviews in Medical Virology
Shaoqiong LiuWeifeng Shi

Abstract

Long noncoding RNAs (lncRNAs) represent a key class of cellular regulators, involved in the modulation and control of multiple biological processes. Distinct classes of lncRNAs are now known to be induced by host cytokines following viral infections. Current evidence demonstrates that lncRNAs play essential roles at the host-pathogen interface regulating viral infections by either innate immune responses at various levels including activation of pathogen recognition receptors or by epigenetic, transcriptional, and posttranscriptional effects. We review the newly described mechanisms underlying the interactions between lncRNAs, cytokines, and metabolites differentially expressed following viral infections; we highlight the regulatory networks of host antiviral responses and emphasize the need for interdisciplinary research between lncRNA biology and immunology to deepen understanding of viral pathogenesis.

References

Jan 1, 1990·Molecular and Cellular Biology·C I BrannanS M Tilghman
Apr 16, 2002·Science·Ruslan Medzhitov, Charles A Janeway
Dec 6, 2002·Nature·Y OkazakiUNKNOWN RIKEN Genome Exploration Research Group Phase I & II Team
Jun 9, 2006·The Journal of General Virology·Sougata SahaPundi N Rangarajan
May 19, 2007·Science·Philipp KapranovThomas R Gingeras
May 25, 2007·Nature·Adrian Bird
Jul 3, 2009·Genes & Development·Jeremy E WiluszDavid L Spector
Aug 20, 2010·Journal of Virology·Anneke FunkAlexander A Khromykh
Nov 30, 2010·Nucleic Acids Research·Paulo P AmaralJohn S Mattick
Feb 26, 2011·Nature Reviews. Immunology·George Hajishengallis, John D Lambris
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sonia SharmaAnjana Rao
Sep 20, 2011·Molecular Cell·Kevin C Wang, Howard Y Chang
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Feb 18, 2012·Nature·Mitchell Guttman, John L Rinn
Jun 6, 2012·Annual Review of Biochemistry·John L Rinn, Howard Y Chang
Jul 31, 2012·Molecular Cell·Je-Hyun YoonMyriam Gorospe
Dec 12, 2012·Biochemical and Biophysical Research Communications·Zhixin YinChangwen Ke
Mar 7, 2013·Genetics·Johnny T Y KungJeannie T Lee
Mar 19, 2013·Cell·Pedro J Batista, Howard Y Chang
Jul 6, 2013·Cell·Igor Ulitsky, David P Bartel
Aug 3, 2013·Science·Susan CarpenterKatherine A Fitzgerald
Aug 13, 2013·Nature Structural & Molecular Biology·Liying YanFuchou Tang

❮ Previous
Next ❯

Citations

Sep 20, 2020·Journal of Personalized Medicine·Izabela ŁasińskaJacek Mackiewicz
May 10, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yuqian HuLijuan Lin

❮ Previous
Next ❯

Methods Mentioned

BETA
chip
ubiquitination
acetylation
deubiquitination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Nature Reviews. Rheumatology
Yuanjia TangNan Shen
Frontiers in Cellular and Infection Microbiology
Weiwei Liu, Chan Ding
© 2021 Meta ULC. All rights reserved