Long QT Syndrome: An Emerging Role for Inflammation and Immunity

Frontiers in Cardiovascular Medicine
Pietro Enea LazzeriniFranco Laghi-Pasini

Abstract

The long QT syndrome (LQTS), classified as congenital or acquired, is a multi-factorial disorder of myocardial repolarization predisposing to life-threatening ventricular arrhythmias, particularly torsades de pointes. In the latest years, inflammation and immunity have been increasingly recognized as novel factors crucially involved in modulating ventricular repolarization. In the present paper, we critically review the available information on this topic, also analyzing putative mechanisms and potential interplays with the other etiologic factors, either acquired or inherited. Accumulating data indicate inflammatory activation as a potential cause of acquired LQTS. The putative underlying mechanisms are complex but essentially cytokine-mediated, including both direct actions on cardiomyocyte ion channels expression and function, and indirect effects resulting from an increased central nervous system sympathetic drive on the heart. Autoimmunity represents another recently arising cause of acquired LQTS. Indeed, increasing evidence demonstrates that autoantibodies may affect myocardial electric properties by directly cross-reacting with the cardiomyocyte and interfering with specific ion currents as a result of molecular mimicry...Continue Reading

References

Nov 1, 1979·Annals of Internal Medicine·T N JamesJ E Carter
Apr 1, 1978·British Heart Journal·J P FinleyR M Freedom
May 1, 1987·Clinical Cardiology·P SareliL Schamroth
May 1, 1994·American Heart Journal·P K SteinB M Conger
Oct 1, 1993·International Journal of Cardiology·S RamamurthyA Malhotra
May 1, 1999·Journal of Autoimmunity·H LessO Binah
Nov 24, 1999·Lancet·S Viskin
Feb 15, 2001·The Journal of Pediatrics·L LibermanR H Pass
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G Q XiaoM Boutjdir
Jul 11, 2001·Journal of Molecular and Cellular Cardiology·Y QuM Boutjdir
Jan 29, 2002·The American Journal of Medicine·Ijaz A Khan
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Barry LondonGuy Salama
Dec 20, 2002·Nature·Kevin J Tracey
Dec 24, 2002·Pharmacotherapy·Minou Khazan, A Scott Mathis
Mar 6, 2004·Clinical Pharmacology and Therapeutics·Kwadwo AmankwaJames E Tisdale
Apr 13, 2004·Arthritis and Rheumatism·Pietro Enea LazzeriniFranco Laghi-Pasini
Feb 5, 2005·Arthritis and Rheumatism·Nathalie Costedoat-ChalumeauJean-Charles Piette
Feb 16, 2005·Astrobiology·Andrew PohorilleMichael A Wilson
Mar 8, 2005·Arthritis and Rheumatism·Hilal Maradit-KremersSherine E Gabriel
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Simone GarciaMilena B P Soares
Aug 3, 2005·The Journal of Clinical Investigation·Dan M Roden, Prakash C Viswanathan
Sep 27, 2005·Journal of Neuroimmunology·Shigeaki SuzukiMasataka Kuwana
Nov 2, 2005·International Journal of Cardiology·Konstantinos P LetsasFotis Kardaras
Nov 9, 2005·The American Journal of Cardiology·Elizabeth S KaufmanMaria Dikshteyn
Dec 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Polina S Petkova-KirovaGuy Salama

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Citations

Jun 5, 2016·Cardiac Electrophysiology Clinics·Mohamed BoutjdirNabil El-Sherif
Sep 17, 2015·Pharmacology & Therapeutics·Nabil El-Sherif, Mohamed Boutjdir
May 20, 2016·Rheumatology International·Ayse Nur TufanEdiz Dalkilic
Jun 3, 2016·European Heart Journal·Pietro Enea LazzeriniFranco Laghi-Pasini
Oct 6, 2016·Frontiers in Cardiovascular Medicine·Pietro Enea LazzeriniFranco Laghi-Pasini
Aug 22, 2016·JACC. Cardiovascular Imaging·Daniel S ChertowRichard T Davey
Jul 18, 2016·Immunologic Research·Pietro Enea LazzeriniFranco Laghi-Pasini
May 5, 2017·Nature Reviews. Cardiology·Pietro Enea LazzeriniMohamed Boutjdir
Dec 14, 2016·Annual Review of Pathology·Laura BaselerDavid M Morens
Feb 7, 2018·Pacing and Clinical Electrophysiology : PACE·Nabil El-SherifMohamed Boutjdir
Dec 27, 2016·Clinical and Experimental Pharmacology & Physiology·Kamalan JeevaratnamChristopher L-H Huang
Apr 13, 2017·Journal of the American Heart Association·Vineeta TanwarLoren E Wold
Apr 1, 2016·Circulation. Arrhythmia and Electrophysiology·Pietro Enea LazzeriniMohamed Boutjdir
May 23, 2019·Arrhythmia & Electrophysiology Review·Nabil El-SherifMohamed Boutjdir
Apr 17, 2020·Pediatric Research·Linda FerranteTorleiv O Rognum
May 12, 2017·Heart·Pietro Enea LazzeriniPier Leopoldo Capecchi
May 8, 2018·Frontiers in Pharmacology·Pietro E LazzeriniPier L Capecchi
Jun 21, 2020·Journal of Clinical Medicine·Gianfranco PiccirilloDamiano Magrì
Jan 23, 2019·Frontiers in Physiology·Alessandra AlíAdemuyiwa S Aromolaran
Dec 21, 2018·Journal of the American Heart Association·Pietro Enea LazzeriniMohamed Boutjdir
Sep 12, 2019·Frontiers in Neurology·Sylvia J BuchmannChristin E Stevens
Dec 19, 2019·Frontiers in Cardiovascular Medicine·Pietro Enea LazzeriniMohamed Boutjdir
Mar 13, 2020·Frontiers in Pharmacology·Kornél KistamásDavid A Eisner
Jul 23, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Philipp KasperHans-Michael Steffen
Oct 20, 2020·Frontiers in Physiology·Mingxian ChenShenghua Zhou
Sep 19, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Kiran Haresh Kumar PatelFu Siong Ng
Sep 26, 2020·JACC. Clinical Electrophysiology·Parinita DherangeUsha Tedrow
Dec 31, 2020·International Journal of Molecular Sciences·Joyce BernardiAdemuyiwa S Aromolaran
Feb 22, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Cheng ChangSheng-Na Han
Oct 17, 2020·International Journal of Clinical Practice·Bashar FteihaEli Ben-Chetrit
Aug 13, 2021·Frontiers in Cellular and Infection Microbiology·Priscila Silva Grijó FaraniOtacilio Cruz Moreira

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