Long-range plasticity between intact hemispheres after contralateral cervical nerve transfer in humans

Journal of Neurosurgery
Chuan-Tao ZuoYu-Dong Gu

Abstract

Peripheral nerve injury in a limb usually causes intrahemispheric functional reorganization of the contralateral motor cortex. Recently, evidence has been emerging for significant interhemispheric cortical plasticity in humans, mostly from studies of direct cortical damage. However, in this study, a long-range interhemispheric plasticity was demonstrated in adults with brachial plexus avulsion injury (BPAI) who had received a contralateral cervical nerve transfer, and this plasticity reversed the BPAI-induced intrahemispheric cortical reorganization. In this study, 8 adult male patients with BPAI were studied using PET scanning. The results indicated that the right somatomotor cortices, which may contribute to the control of the injured limb before brachial plexus deafferentation, still played an important role when patients with BPAI tried to move their affected limbs, despite the fact that the contralateral C-7 nerve transfer had been performed and the peripheral output had changed dramatically. Such findings are consistent with the results of the authors' previous animal study. The brain may try to restore the control of an injured limb to its original cortex area, and a complicated change of peripheral pathway also can indu...Continue Reading

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Citations

Feb 5, 2013·Journal of Neurosurgery·Xu-Yun HuaYu-Dong Gu
Jan 24, 2014·Human Brain Mapping·Elena Solesio-JofreStephan P Swinnen
Apr 28, 2016·Hand Surgery and Rehabilitation·Su JiangPhilippe Liverneaux
Dec 15, 2017·Chinese Medical Journal·Wen-Jun LiYu-Dong Gu
May 11, 2018·British Journal of Neurosurgery·Fardad T AfshariDominic M Power

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BETA
SMA
imaging techniques
amputation

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