Long-standing bullous keratopathy is associated with peripheral conjunctivalization and limbal deficiency

Ophthalmology
Yuichi UchinoJun Shimazaki

Abstract

To investigate whether peripheral corneal neovascularization in bullous keratopathy (BK) is due to conjunctivalization, a sign of limbal stem cell deficiency. Observational case-control study. Sixteen BK patients. Patients were divided into 2 groups: BK without peripheral neovascularization [NV(-) group; 5 patients, 5 eyes] and BK with neovascularization [NV(+) group; 11 patients, 13 eyes]. Evidence of conjunctivalization was evaluated by periodic acid-Schiff staining of impression cytology samples from the peripheral vascularized cornea. The 2 groups' durations of disease also were compared. Penetrating keratoplasty (PK) was performed in all 16 cases, and the 2 groups' durations of reepithelialization after PK were compared. Presence of goblet cells using impression cytology, duration of BK, and duration of postoperative reepithelialization. Goblet cells were found on the peripheral corneal surface in all eyes in the NV(+) group. However, all eyes in the NV(-) group were negative for goblet cells (P<0.0001). Duration of disease was 14.4+/-5.4 months in the NV(-) group and 66.2+/-65.5 months in the NV(+) group (P = 0.030). Duration of postoperative epithelialization was 6.2+/-2.2 days in the NV(-) group and 28.8+/-36.5 days in ...Continue Reading

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Citations

Aug 31, 2010·Cornea·Leonardo N SantosMiguel N Burnier
Jun 1, 2013·The British Journal of Ophthalmology·Fabiana dos Santos ParisJosé Álvaro Pereira Gomes
Mar 24, 2009·Journal of Cataract and Refractive Surgery·Takefumi YamaguchiKazuo Tsubota
Feb 7, 2009·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Raul Martin
Sep 25, 2008·Journal of Cataract and Refractive Surgery·Mehrdad Mohammadpour, Mahmood Jabbarvand
Mar 21, 2008·Clinical & Experimental Ophthalmology·Nick S GeorgiadisDimitrios G Mikropoulos
Nov 4, 2011·Ophthalmology·Eliana D GonçalvesMauro Campos
Jan 8, 2019·Cornea·Sophie X DengUNKNOWN and The International Limbal Stem Cell Deficiency Working Group
Jan 25, 2020·Cornea·Yuzhao SunSophie X Deng
Feb 12, 2021·Experimental Eye Research·Clémence BonnetSophie X Deng

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