Long-term 1-carnitine treatment prolongs the survival in rats with adriamycin-induced heart failure

Journal of Cardiac Failure
N KawasakiT Ueda

Abstract

The most serious consequence of heart failure is the shortened life expectancy, which may be associated with myocardial energy starvation. Eight-week-old male Sprague-Dawley rats received 6 intraperitoneal injections of adriamycin (group A: total dose; 15 mg/kg body weight) or vehicle (group C) over 2 weeks. Rats then received either 272 mg/kg daily of oral 1-carnitine (A-LC and C-LC groups) or saline (A-S and C-S groups) for 6 weeks. The cumulative mortality rate in the A-LC group was significantly lower than in the A-S group (13 vs 42%, P = .028). Myocardial levels of high-energy phosphate compounds (ATP and creatine phosphate) and fatty acid metabolites (free carnitine, short-chain and long-chain acylcarnitine, and long-chain acyl CoA) in the left ventricle were measured the day after the last dose of drug or vehicle was administered. ATP was decreased by 73%, creatine phosphate by 61%, free carnitine by 52%, short-chain acylcarnitine by 48%, and long-chain acylcarnitine by 56% in the A-S group compared to the C-S group. Long-chain CoA was increased by 168% in the A-S group. Levels of myocardial high-energy phosphate compounds and fatty acid metabolites were near normal in adriamycin- and 1-carnitine-treated rats. Preservati...Continue Reading

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Citations

Aug 18, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ibrahim KocerKorkmaz Serifoglu
Jun 6, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gurusher Singh Panjrath, Diwakar Jain
Dec 1, 1996·Journal of Cardiac Failure·A M Katz
Jul 7, 2011·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Anant KhositsethDuangrurdee Wattanasirichaigoon
Dec 13, 2000·European Journal of Heart Failure·K TeraokaA Yamashina
Mar 30, 2007·Journal of Endocrinological Investigation·Z XuG Liu
Feb 23, 2011·Journal of Proteomics·Suresh N KumarBalaraman Kalyanaraman
Jun 23, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M M Sayed-AhmedM Calvani
Nov 28, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R G Ahmed, S Incerpi
Aug 27, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N Andrieu-AbadieJ J Mercadier
Dec 19, 2013·Human & Experimental Toxicology·Ab IbrahimS M Abu El Nour

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