Long-term (10-year) gastrointestinal and genitourinary toxicity after treatment with external beam radiotherapy, radical prostatectomy, or brachytherapy for prostate cancer.

Prostate Cancer
Grant K HunterJay P Ciezki

Abstract

Objective.To examine gastrointestinal (GI) and genitourinary (GU) toxicity profiles of patients treated in 1999 with external beam radiotherapy (RT), prostate interstitial brachytherapy (PI) or radical prostatectomy (RP). Methods. TThe records of 525 patients treated in 1999 were reviewed to evaluate toxicity. Late GI and GU morbidities were graded according to the RTOG late morbidity criteria. Other factors examined were patient age, BMI, smoking history, and medical co-morbidities. Due to the low event rate for late GU and GI toxicities, a competing risk regression (CRR) analysis was done with death as the competing event. Results. Median follow-up time was 8.5 years. On CRR univariate analysis, only the presence of DM was significantly associated with GU toxicity grade >2 (P = 0.43, HR 2.35, 95% Cl = 1.03-5.39). On univariate analysis, RT and DM were significantly associated with late GI toxicity. On multivariable analysis, both variables remained significant (RT: P = 0.038, HR = 4.71, CI = 1.09-20.3; DM: P = 0.008, HR = 3.81, 95% Cl = 1.42-10.2). Conclusions. Late effects occur with all treatment modalities. The presence of DM at the time of treatment was significantly associated with worse late GI and GU toxicity. RT was s...Continue Reading

References

Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·T E SchultheissG E Hanks
Mar 17, 1999·International Journal of Radiation Oncology, Biology, Physics·D M HeroldG E Hanks
Mar 4, 2000·International Journal of Radiation Oncology, Biology, Physics·D S MohanT R Willoughby
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·D A WilkinsonD Mohan
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Alan PollackIsaac Rosen
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James A TalcottAnthony V D'Amico
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David C MillerJohn T Wei
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Patrick A KupelianArul Mahadevan
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sang Min ParkYoung Ho Yun
Jan 19, 2007·International Journal of Cancer. Journal International Du Cancer·Lonneke V van de Poll-FranseHarm R Haak
Jun 5, 2007·International Journal of Radiation Oncology, Biology, Physics·Patrick A KupelianArul Mahadevan
Nov 13, 2007·International Journal of Radiation Oncology, Biology, Physics·Patrick A KupelianArul Mahadevan
Mar 21, 2008·The New England Journal of Medicine·Martin G SandaJohn T Wei
Sep 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R SmithWilliam U Shipley
Dec 18, 2008·JAMA : the Journal of the American Medical Association·Bethany B BaroneFrederick L Brancati
Feb 13, 2009·International Journal of Radiation Oncology, Biology, Physics·Mira KeyesW James Morris
Nov 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Anthony V D'AmicoMing-Hui Chen
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Eric E YeohJack Fowler

❮ Previous
Next ❯

Citations

Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Feb 1, 2013·Oxidative Medicine and Cellular Longevity·Alina WoźniakAnna Szpinda
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Bregje van OorschotNicolaas A P Franken
Oct 31, 2013·Clinical Genitourinary Cancer·Matthew C WardEric A Klein
Nov 22, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro KimuraShin Egawa
May 13, 2015·International Journal of Radiation Oncology, Biology, Physics·Jeffrey A KittelJay P Ciezki
Dec 19, 2014·Radiation Oncology·Elina Korpela, Stanley K Liu
Mar 19, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stine Elleberg PetersenMorten Høyer
Jul 13, 2016·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Ruijie YangAng Qu
Jul 16, 2013·Urologia·Francesco PintoPierfrancesco Bassi
Sep 10, 2014·PloS One·Richéal M BurnsCiaran O Neill
Jan 22, 2017·International Journal of Colorectal Disease·Gustavo Arruda Viani, Aline Sakamoto
Aug 13, 2013·International Journal of Cancer. Journal International Du Cancer·Anthony J ApostoliChristopher J B Nicol
Mar 23, 2021·Brachytherapy·Elizabeth Thompson, William Barrett

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Software Mentioned

SAS
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.