Long-term abnormalities in T and B lymphocyte function in children following treatment for acute lymphoblastic leukaemia

British Journal of Haematology
L LaywardM Butler

Abstract

T and B lymphocyte function as assessed by pokeweed mitogen stimulation and concanavalin A suppression was studied in 40 children with acute lymphoblastic leukaemia who were in remission and off all treatment. Both plasma cell and immunoglobulin production was reduced in off-treatment patients, particularly in those who had received cyclophosphamide as part of their treatment. The ability to suppress immunoglobulin production was also significantly reduced in these patients. These abnormalities were long-standing and were apparent up to 5 years after stopping treatment with no indication of a return to normality. No clinical correlations have been observed.

References

Jan 1, 1977·Haematology and Blood Transfusion·M F GreavesD Catovsky
Oct 11, 1979·The New England Journal of Medicine·K B Miller, R S Schwartz
Jan 1, 1975·Cancer·J V SimoneD Pinkel
Mar 1, 1981·General and Comparative Endocrinology·S W FarmerH Papkoff

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Citations

Feb 16, 1984·The New England Journal of Medicine·J FeehallyR J Postlethwaite
Nov 5, 1997·Journal of Pediatric Hematology/oncology·T LehrnbecherS J Chanock
Aug 1, 1991·Acta Paediatrica Japonica; Overseas Edition·M YamamotoS Miyazaki
Jan 1, 1985·The Journal of Clinical Investigation·S LiR P Gale
Sep 29, 2011·Pediatric Blood & Cancer·Antonio RuggieroRiccardo Riccardi
Sep 1, 1987·European Journal of Cancer & Clinical Oncology·A JermyR C Rees
Sep 14, 2007·Pediatric Blood & Cancer·Sofia KosmidisHelen Vasilatou-Kosmidis
Oct 27, 1998·Journal of Pediatric Hematology/oncology·M M MustafaM S Agopian

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