Long-term action of potassium bromide on the rat thyroid gland

Acta histochemica
J VelickýI Raska

Abstract

Male rats fed by a standard diet with determined of bromine and iodine content were exposed to a 133-day oral administration of KBr (100, 200, 400 mg Br-/l drinking water). Their thyroid glands showed increased growth of the epithelial cells reflected by a microfollicular rearrangement of the parenchyma due to proliferation of very small follicles with a low or zero content of colloid. Morphometric analysis of thyroids of Br(-)-exposed animals revealed a significant decrease in the volume of intrafollicular colloid and marked increase in the number of the smallest follicles (areas up to 100 and 100-300 micron 2). In addition, the nuclei of thyrocytes showed an increased number of mitoses. The vascularization was increased as well. In the blood plasma of the Br(-)-exposed animals the T4 concentration was significantly decreased in dependence on the bromine concentrations. Thyroglobulin immunoreactivity in the colloid of Br(-)-exposed animals decreased after administration of 400 mg Br-/l drinking water. Increasing concentrations of Br- in the drinking water caused an increased bromine concentration in the thyroid, a decreased iodine content and a decreased I/Br molar ratio. The changes in the rat thyroid caused by long-term admi...Continue Reading

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Citations

Jun 4, 2008·Folia Histochemica Et Cytobiologica·Monika A PapiezAgata Gebarowska
Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Dana KotyzováEystein Glattre
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Jun 1, 2016·Annals of the New York Academy of Sciences·Adam LamSaurabh Aggarwal
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Jul 7, 2020·EFSA Journal·UNKNOWN European Food Safety Authority (EFSA)Luc Mohimont
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May 16, 2020·International Journal of Molecular Sciences·Pasqualino MalandrinoRiccardo Vigneri

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