Long-term administration of a sucrose-rich diet to normal rats: relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas

Metabolism: Clinical and Experimental
Yolanda B LombardoC L Gómez Dumm

Abstract

The aim of the present investigation was to study normal rats fed a sucrose-rich diet (SRD) for a prolonged period (up to 30 weeks) (1) to obtain additional data on the hormonal and metabolic patterns induced by this treatment and (2) to provide information on changes taking place in the pancreatic islet cell populations. We found that long-term feeding with a SRD resulted in a steady state of hypertriglyceridemia and hyperglycemia in which insulin levels remained unchanged and unable to compensate for the increased demands of the developing metabolic changes. The endocrine pancreas showed a significant increase of both islet number and B-cell area, as well as changes in the profile of islet cell distribution. However, these changes were not accompanied by an increase in the pancreatic content of immunoreactive insulin (IRI). It may therefore be postulated that the newly emerged B-cell mass has some sort of derangement with the increased insulin demand resulting from insulin resistance induced by the long-term SRD feeding. Thus, feeding a SRD to normal rats may prove to be an attractive animal model for studying the role of environmental nutritional factors in the unsettled issue of the relationship between insulin resistance a...Continue Reading

References

Nov 1, 1979·The Journal of Nutrition·J HallfrischS Reiser
Mar 1, 1978·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A M Cohen
Jan 1, 1977·Metabolism: Clinical and Experimental·A M CohenE Rosenman
Jan 1, 1977·Metabolism: Clinical and Experimental·L Herberg, D L Coleman
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C L Gomez DummJ J Gagliardino
Jun 1, 1989·The American Journal of Clinical Nutrition·A W ThorburnE W Kraegen
Jul 1, 1988·The Journal of Clinical Investigation·A B JenkinsE W Kraegen
Apr 1, 1986·Metabolism: Clinical and Experimental·G Strömblad, P Björntorp
May 1, 1986·The Journal of Clinical Investigation·P ArnerJ Livingston
Nov 1, 1987·Metabolism: Clinical and Experimental·R A GutmanY B Lombardo
Oct 1, 1985·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R GutmanY B Lombardo
Jan 1, 1966·Scandinavian Journal of Clinical and Laboratory Investigation·S Laurell
Jan 1, 1969·International Review of Cytology·E R Weibel
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Jan 1, 1983·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Y B LombardoR Gutman
Jun 1, 1984·Diabetologia·C Hellerström
Nov 1, 1982·Metabolism: Clinical and Experimental·I ZavaroniG M Reaven
Feb 1, 1981·The Journal of Nutrition·S R BlakelyE S Prather
Sep 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A ChiccoY B Lombardo
Sep 10, 1962·Biochimica Et Biophysica Acta·P R DAVOREN
Jul 1, 1963·The Biochemical Journal·W G Duncombe

❮ Previous
Next ❯

Citations

Jul 27, 2001·Archives of Physiology and Biochemistry·J UkropecI Klimes
Aug 7, 2002·The Journal of Nutrition·Elodie Peyron-CasoSalwa W Rizkalla
Nov 6, 2010·Veterinary Pathology·P VogelM Shadoan
Feb 8, 2014·Canadian Journal of Physiology and Pharmacology·Hussein F SakrMohamed D Morsy
Jun 11, 1999·Diabetes/metabolism Research and Reviews·H Del ZottoJ J Gagliardino
Jun 22, 2005·World Journal of Gastroenterology : WJG·Jing AiBao-Feng Yang
May 22, 2013·Journal of Diabetes Research·Alexandre M LehnenBeatriz D'Agord Schaan
Apr 8, 2018·Clinical Science·Bárbara MaizteguiLuis Emilio Flores
Jan 15, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Agustina CreusYolanda Bolzón de Lombardo
Mar 9, 2000·Diabetes/metabolism Research and Reviews·J J Gagliardino
Nov 5, 2002·Depression and Anxiety·Arthur N Westover, Lauren B Marangell
Dec 3, 2009·American Journal of Physiology. Endocrinology and Metabolism·Gustavo J HeinRodolfo R Brenner
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Sunil K Panchal, Lindsay Brown
Feb 12, 2017·Clinical Science·Bárbara MaizteguiJuan J Gagliardino
Jul 2, 2009·The British Journal of Nutrition·Megumi MatsumotoTakaji Yajima
Feb 17, 2001·The Journal of Nutritional Biochemistry·M -H. YangH -L. Chen
Nov 13, 2004·The Journal of Nutritional Biochemistry·M MontesY B Lombardo
Aug 23, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Geovana M X EbaidEthel L B Novelli
Oct 11, 2005·The Journal of Nutritional Biochemistry·Yolanda B Lombardo, Adriana G Chicco
Dec 13, 2006·Metabolism: Clinical and Experimental·Hidekazu AraiEiji Takeda
Jun 17, 2008·Metabolism: Clinical and Experimental·María Eugenia D'AlessandroYolanda B Lombardo
Apr 20, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Louis JacobAi Koyanagi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.