PMID: 8613901Apr 1, 1996Paper

Long-term administration of high dose vitamin A to rats does not cause fetal malformations: macroscopic, skeletal and physicochemical findings

The Journal of Nutrition
H K BiesalskiE Stofft

Abstract

A rat model was used to investigate whether high oral doses of vitamin A lead to fetal malformations and to what extent retinyl esters (RES) are transferred from the mother to the fetuses. Retinol and RES concentrations in plasma behave similarly in rats and humans. When high concentrations of vitamin A are administered, plasma retinol concentrations remain relatively constant, whereas plasma RES increased in parallel with the dose. To achieve an elevation from approximately 150 to > 1525 nmol x L(-1) in the experimental group before mating, female Ibm: RORO (spf) rats were fed a maintenance diet enriched with 15.2 x 10(3) retinol equivalents (RE) x kg(-1) at the start and increased stepwise to 52.5 x 10(3) for a total of 8 mo. A parallel subgroup was maintained to measure progress in experimental rats without interference by blood taking. Rats of the control group received the basal diet analyzed to contain 4.5 x 10(3) RE x kg(-1). Before mating the mean body weights of experimental and control rats were not significantly different. All-trans, 13-cis, 4-oxo-all-trans and 5,6-epoxy-all-trans retinoic acid (RA) concentrations were determined in maternal and fetal plasma. With high vitamin A intake, 4-oxo- and 5,6-epoxy RA concen...Continue Reading

Citations

Jan 30, 2009·Journal of Clinical Biochemistry and Nutrition·George A AsareChristiana P Kahler-Venter
Oct 14, 2017·International Journal of Toxicology·Wilbur Johnson
Feb 2, 2002·The Journal of Nutrition·Florian J Schweigert, Jens Raila
Jul 16, 2002·Biochimica Et Biophysica Acta·Carsten K SchmidtHeinz Nau

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