Long-term alteration in maternal blood pressure and renal function after pregnancy in normal and growth-restricted rats

Hypertension
Linda A GalloMary E Wlodek

Abstract

Intrauterine growth restriction is associated with increased risk of adult cardiorenal diseases. Small birth weight females are more likely to experience complications during their own pregnancy, including pregnancy-induced hypertension, preeclampsia, and gestational diabetes. We determined whether the physiological demand of pregnancy predisposes growth-restricted females to cardiovascular and renal dysfunction later in life. Late gestation bilateral uterine vessel ligation was performed in Wistar-Kyoto rats. At 4 months, restricted and control female offspring were mated with normal males and delivered naturally (ex-pregnant). Regardless of maternal birth weight, at 13 months, ex-pregnant females developed elevated mean arterial pressure (indwelling tail-artery catheter; +6 mm Hg), reduced effective renal blood flow ((14)C-PAH clearance; -23%), and increased renal vascular resistance (+27%) compared with age-matched virgins. Glomerular filtration rate ((3)H-inulin clearance) was not different across groups. This adverse cardiorenal phenotype in ex-pregnant females was associated with elevated systemic (+57%) and altered intrarenal components of the renin-angiotensin system. After pregnancy at 13 months, coronary flow (Langend...Continue Reading

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Citations

Apr 16, 2013·Clinical and Experimental Pharmacology & Physiology·Linda A GalloMary E Wlodek
Aug 6, 2013·Current Cardiovascular Risk Reports·Suttira Intapad, Barbara T Alexander
Sep 10, 2014·Clinical and Experimental Pharmacology & Physiology·Jordanna S MasterMary J Black
Mar 21, 2015·Environmental Health Perspectives·Shohreh F FarzanMargaret R Karagas
Sep 9, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·S B CorvinoD C Damasceno
Jul 10, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Linda A GalloMary E Wlodek
Feb 12, 2019·Fetal and Pediatric Pathology·Tyrus StewartDiego H Aviles
Aug 6, 2013·Reproduction, Fertility, and Development·Linda A GalloMary E Wlodek
Feb 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie TranMary E Wlodek

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