Long-term alterations in growth factor mRNA expression following seizures

Neuroreport
M L GarciaA J Windebank

Abstract

Although alterations in growth factor mRNA occur during neuronal insults, little is known about the long-term effects of neuronal insults on growth factor expression. We have examined the effects of prolonged post-ictal times on the expression of Brain-derivered nerve factor (BDNF) and Neurotrophin 3 (NT3) following Kainic acid (KA)-induced seizures. In situ hybridization was performed on male Sprague-Dawley rats sacrificed 1-2 weeks following intracranial ventricular KA injections. BDNF mRNA increased bilaterally 1 and 2 weeks after injections, whereas NT3 mRNA decreased contralaterally 1 week and bilaterally 2 weeks post-injection. These observations provide evidence that alterations in growth factor mRNA expression occur even after prolonged post-ictal recovery suggesting a possible role for growth factors in recovery and continued maintenance of surviving neurons within limbic seizure foci.

References

Jan 1, 1991·Brain Research. Molecular Brain Research·C GallP J Isackson
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R RacineS Chipashvili

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Citations

Dec 22, 2000·Progress in Neurobiology·J L Jankowsky, P H Patterson
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·E S LeinC J Shatz
Oct 3, 1999·Experimental Neurology·J L Jankowsky, P H Patterson
Apr 4, 2000·The Journal of Comparative Neurology·E S LeinC J Shatz
Dec 8, 2004·Journal of Neuropathology and Experimental Neurology·Jhodie R DuncanSandra M Rees

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